Establishment of leukemia inhibitory factor (LIF)-independent iPS cells with potentiated Oct4

Establishment of leukemia inhibitory factor (LIF)-independent iPS cells with potentiated Oct4

Leukemia inhibitory factor (LIF) is widely used to establish and maintain naïve pluripotent stem cells, including mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Although the combination of chemical inhibitors called 2i can establish mouse iPSCs without LIF from primed...

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Bibliographic Details
Main Authors: Hiroyuki Hirai, Meri Firpo, Nobuaki Kikyo
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Stem Cell Research
Subjects:
Induced pluripotent stem cells
Leukemia inhibitory factor
miRNA
Pluripotency
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506115001154

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