Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children
Background/purpose: Influenza is frequently complicated with bacterial co-infection. This study aimed to disclose the significance of Streptococcus pneumoniae co-infection in children with influenza. Methods: We retrospectively reviewed medical records of pediatric patients hospitalized for influenz...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664621003430 |
| _version_ | 1818278156612665344 |
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| author | Tzu-Yun Hsing Chun-Yi Lu Luan-Yin Chang Yun-Chung Liu Hsiao-Chi Lin Li-Lun Chen Yu-Cheng Liu Ting-Yu Yen Jong-Min Chen Ping-Ing Lee Li-Min Huang Fei-Pei Lai |
| author_facet | Tzu-Yun Hsing Chun-Yi Lu Luan-Yin Chang Yun-Chung Liu Hsiao-Chi Lin Li-Lun Chen Yu-Cheng Liu Ting-Yu Yen Jong-Min Chen Ping-Ing Lee Li-Min Huang Fei-Pei Lai |
| author_sort | Tzu-Yun Hsing |
| collection | DOAJ |
| description | Background/purpose: Influenza is frequently complicated with bacterial co-infection. This study aimed to disclose the significance of Streptococcus pneumoniae co-infection in children with influenza. Methods: We retrospectively reviewed medical records of pediatric patients hospitalized for influenza with or without pneumococcal co-infection at the National Taiwan University Hospital from 2007 to 2019. Clinical characteristics and outcomes were compared between patients with and without S. pneumoniae co-infection. Results: There were 558 children hospitalized for influenza: 494 had influenza alone whereas 64 had S. pneumoniae co-infection. Patients with S. pneumoniae co-infection had older ages, lower SpO2, higher C-Reactive Protein (CRP), lower serum sodium, lower platelet counts, more chest radiograph findings of patch and consolidation on admission, longer hospitalization, more intensive care, longer intensive care unit (ICU) stay, more mechanical ventilation, more inotropes/vasopressors use, more surgical interventions including video-assisted thoracoscopic surgery (VATS) and extracorporeal membrane oxygenation (ECMO), and higher case-fatality rate. Conclusion: Compared to influenza alone, patients with S. pneumoniae co-infection had more morbidities and mortalities. Pneumococcal co-infection is considered when influenza patients have lower SpO2, lower platelet counts, higher CRP, lower serum sodium, and more radiographic patches and consolidations on admission. |
| first_indexed | 2024-12-12T23:12:58Z |
| format | Article |
| id | doaj.art-a385f1c43d91402a8068427f991d5a64 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-12T23:12:58Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-a385f1c43d91402a8068427f991d5a642022-12-22T00:08:33ZengElsevierJournal of the Formosan Medical Association0929-66462022-05-011215950957Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in childrenTzu-Yun Hsing0Chun-Yi Lu1Luan-Yin Chang2Yun-Chung Liu3Hsiao-Chi Lin4Li-Lun Chen5Yu-Cheng Liu6Ting-Yu Yen7Jong-Min Chen8Ping-Ing Lee9Li-Min Huang10Fei-Pei Lai11Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 8, Chung Shan S. Rd., Taipei 10002, Taiwan. Fax: +886 2 23147450.Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, TaiwanDivision of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan; Department of Electrical Engineering, National Taiwan University, Taipei, TaiwanBackground/purpose: Influenza is frequently complicated with bacterial co-infection. This study aimed to disclose the significance of Streptococcus pneumoniae co-infection in children with influenza. Methods: We retrospectively reviewed medical records of pediatric patients hospitalized for influenza with or without pneumococcal co-infection at the National Taiwan University Hospital from 2007 to 2019. Clinical characteristics and outcomes were compared between patients with and without S. pneumoniae co-infection. Results: There were 558 children hospitalized for influenza: 494 had influenza alone whereas 64 had S. pneumoniae co-infection. Patients with S. pneumoniae co-infection had older ages, lower SpO2, higher C-Reactive Protein (CRP), lower serum sodium, lower platelet counts, more chest radiograph findings of patch and consolidation on admission, longer hospitalization, more intensive care, longer intensive care unit (ICU) stay, more mechanical ventilation, more inotropes/vasopressors use, more surgical interventions including video-assisted thoracoscopic surgery (VATS) and extracorporeal membrane oxygenation (ECMO), and higher case-fatality rate. Conclusion: Compared to influenza alone, patients with S. pneumoniae co-infection had more morbidities and mortalities. Pneumococcal co-infection is considered when influenza patients have lower SpO2, lower platelet counts, higher CRP, lower serum sodium, and more radiographic patches and consolidations on admission.http://www.sciencedirect.com/science/article/pii/S0929664621003430ChildrenCo-infectionInfluenzaOutcomeStreptococcus pneumoniae |
| spellingShingle | Tzu-Yun Hsing Chun-Yi Lu Luan-Yin Chang Yun-Chung Liu Hsiao-Chi Lin Li-Lun Chen Yu-Cheng Liu Ting-Yu Yen Jong-Min Chen Ping-Ing Lee Li-Min Huang Fei-Pei Lai Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children Journal of the Formosan Medical Association Children Co-infection Influenza Outcome Streptococcus pneumoniae |
| title | Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children |
| title_full | Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children |
| title_fullStr | Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children |
| title_full_unstemmed | Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children |
| title_short | Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children |
| title_sort | clinical characteristics of influenza with or without streptococcus pneumoniae co infection in children |
| topic | Children Co-infection Influenza Outcome Streptococcus pneumoniae |
| url | http://www.sciencedirect.com/science/article/pii/S0929664621003430 |
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