Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles
Fan Zhang,1 Yi-Nuo Yang,2 Jin-Di Feng,2 Jing-Hui Zhao,1 Li Wan,1 Jing Che,1 Ying Yan,1 Ning-Ning Guo,1 Jia-Yu Zhang1 1Hair Medical Research Center, Department of Dermatology and Venereology, Beijing Jishuitan Hospital, Beijing, People’s Republic of China; 2School of Clinical Medicine, Peking Univers...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-11-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/observation-on-the-efficacy-of-a-combined-treatment-for-moderate-and-s-peer-reviewed-fulltext-article-CCID |
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| author | Zhang F Yang YN Feng JD Zhao JH Wan L Che J Yan Y Guo NN Zhang JY |
| author_facet | Zhang F Yang YN Feng JD Zhao JH Wan L Che J Yan Y Guo NN Zhang JY |
| author_sort | Zhang F |
| collection | DOAJ |
| description | Fan Zhang,1 Yi-Nuo Yang,2 Jin-Di Feng,2 Jing-Hui Zhao,1 Li Wan,1 Jing Che,1 Ying Yan,1 Ning-Ning Guo,1 Jia-Yu Zhang1 1Hair Medical Research Center, Department of Dermatology and Venereology, Beijing Jishuitan Hospital, Beijing, People’s Republic of China; 2School of Clinical Medicine, Peking University School of Medicine, Beijing, People’s Republic of ChinaCorrespondence: Fan Zhang, Hair Medical Research Center, Department of Dermatology and Venereology, Beijing Jishuitan Hospital, No. 31 of Xinjiekou East Street, Xicheng District, Beijing, 100035, People’s Republic of China, Tel +86 10 58516688, Email zhangfanzf63z@126.comObjective: To evaluate the effectiveness and safety of a combined treatment for moderate and severe androgenetic alopecia (AGA) involving the use of electric microneedles.Methods: A total of 83 patients with moderate to severe AGA in the Department of Dermatology at Beijing Jishuitan Hospital were included in this study. The male patients were administered finasteride orally and 5% minoxidil for external use, while the female patients were given spironolactone orally or Diane-35 and 2% minoxidil for external use. All the patients were then treated via electric microneedle therapy alongside the YUFA ®medical care package (Foshan, China) once a week for 1– 28 weeks. The seven-point method and root hair measurement using a hair mirror were adopted to evaluate the efficacy and any adverse reactions of the combined treatment.Results: Eleven patients were treated for 1– 3 weeks, 60 for 4– 12 weeks, and 12 for more than 12 weeks. The efficacy evaluation using the seven-point method for 12 weeks of treatment indicated a 100% response rate, specifically, a 42.1% mild improvement rate, a 38.6% moderate improvement rate, and a 19.3% marked improvement rate. Besides, the efficacy assessment was also completed with root hair count method and the number of hair roots measured at fixed points were 148.67± 11.15, 158.13± 5.11 and 169.75± 2.06 after treatment time at 16, 20 and 24 weeks, respectively. Of note, a statistical difference in the number of hair roots could be observed during the period of week 20–week 24 (P < 0.01).Conclusion: The combined treatment of moderate to severe AGA using the electric microneedle technique has a clear effect and can effectively increase the hair density. With a simple operation and mild side effects, the technique has wide application prospects.Keywords: electric microneedles, androgenic alopecia, combined therapy, efficacy observation |
| first_indexed | 2024-04-12T05:21:31Z |
| format | Article |
| id | doaj.art-a3879d7401294dc9b352a93b386997cc |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-04-12T05:21:31Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-a3879d7401294dc9b352a93b386997cc2022-12-22T03:46:28ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152022-11-01Volume 152573258179986Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric MicroneedlesZhang FYang YNFeng JDZhao JHWan LChe JYan YGuo NNZhang JYFan Zhang,1 Yi-Nuo Yang,2 Jin-Di Feng,2 Jing-Hui Zhao,1 Li Wan,1 Jing Che,1 Ying Yan,1 Ning-Ning Guo,1 Jia-Yu Zhang1 1Hair Medical Research Center, Department of Dermatology and Venereology, Beijing Jishuitan Hospital, Beijing, People’s Republic of China; 2School of Clinical Medicine, Peking University School of Medicine, Beijing, People’s Republic of ChinaCorrespondence: Fan Zhang, Hair Medical Research Center, Department of Dermatology and Venereology, Beijing Jishuitan Hospital, No. 31 of Xinjiekou East Street, Xicheng District, Beijing, 100035, People’s Republic of China, Tel +86 10 58516688, Email zhangfanzf63z@126.comObjective: To evaluate the effectiveness and safety of a combined treatment for moderate and severe androgenetic alopecia (AGA) involving the use of electric microneedles.Methods: A total of 83 patients with moderate to severe AGA in the Department of Dermatology at Beijing Jishuitan Hospital were included in this study. The male patients were administered finasteride orally and 5% minoxidil for external use, while the female patients were given spironolactone orally or Diane-35 and 2% minoxidil for external use. All the patients were then treated via electric microneedle therapy alongside the YUFA ®medical care package (Foshan, China) once a week for 1– 28 weeks. The seven-point method and root hair measurement using a hair mirror were adopted to evaluate the efficacy and any adverse reactions of the combined treatment.Results: Eleven patients were treated for 1– 3 weeks, 60 for 4– 12 weeks, and 12 for more than 12 weeks. The efficacy evaluation using the seven-point method for 12 weeks of treatment indicated a 100% response rate, specifically, a 42.1% mild improvement rate, a 38.6% moderate improvement rate, and a 19.3% marked improvement rate. Besides, the efficacy assessment was also completed with root hair count method and the number of hair roots measured at fixed points were 148.67± 11.15, 158.13± 5.11 and 169.75± 2.06 after treatment time at 16, 20 and 24 weeks, respectively. Of note, a statistical difference in the number of hair roots could be observed during the period of week 20–week 24 (P < 0.01).Conclusion: The combined treatment of moderate to severe AGA using the electric microneedle technique has a clear effect and can effectively increase the hair density. With a simple operation and mild side effects, the technique has wide application prospects.Keywords: electric microneedles, androgenic alopecia, combined therapy, efficacy observationhttps://www.dovepress.com/observation-on-the-efficacy-of-a-combined-treatment-for-moderate-and-s-peer-reviewed-fulltext-article-CCIDelectric microneedlesandrogenic alopeciacombined therapyefficacy observation |
| spellingShingle | Zhang F Yang YN Feng JD Zhao JH Wan L Che J Yan Y Guo NN Zhang JY Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles Clinical, Cosmetic and Investigational Dermatology electric microneedles androgenic alopecia combined therapy efficacy observation |
| title | Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles |
| title_full | Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles |
| title_fullStr | Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles |
| title_full_unstemmed | Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles |
| title_short | Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles |
| title_sort | observation on the efficacy of a combined treatment for moderate and severe androgenetic alopecia incorporating electric microneedles |
| topic | electric microneedles androgenic alopecia combined therapy efficacy observation |
| url | https://www.dovepress.com/observation-on-the-efficacy-of-a-combined-treatment-for-moderate-and-s-peer-reviewed-fulltext-article-CCID |
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