Human Metapneumovirus Genetic Variability, South Africa
The molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000–2002) from viruses that were identified in South Africa. Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2–6 possible gen...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2005-07-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/11/7/05-0050_article |
| _version_ | 1818173463093837824 |
|---|---|
| author | Herbert P. Ludewick Yacine Abed Nadia van Niekerk Guy Boivin Keith P. Klugman Shabir A. Madhi |
| author_facet | Herbert P. Ludewick Yacine Abed Nadia van Niekerk Guy Boivin Keith P. Klugman Shabir A. Madhi |
| author_sort | Herbert P. Ludewick |
| collection | DOAJ |
| description | The molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000–2002) from viruses that were identified in South Africa. Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2–6 possible genotypes within the subgroups. A shift in the predominant group was documented in successive seasons. Whereas the F gene was relatively conserved between subgroups, a high degree of variation was observed in the extracellular domain of the G gene of the virus. The G protein identities between groups A and B were 45.1%–53.1% at the nucleotide level and 22.4%–27.6% at the amino acid level. These results provide evidence for the diversity of both surface glycoproteins of hMPV in Africa, which may be a prerequisite to understanding protective immunity against hMPV. |
| first_indexed | 2024-12-11T19:28:54Z |
| format | Article |
| id | doaj.art-a387b88f5cf54675a6b9733622c4ca54 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T19:28:54Z |
| publishDate | 2005-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-a387b88f5cf54675a6b9733622c4ca542022-12-22T00:53:19ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592005-07-011171074107810.3201/eid1107.050050Human Metapneumovirus Genetic Variability, South AfricaHerbert P. LudewickYacine AbedNadia van NiekerkGuy BoivinKeith P. KlugmanShabir A. MadhiThe molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000–2002) from viruses that were identified in South Africa. Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2–6 possible genotypes within the subgroups. A shift in the predominant group was documented in successive seasons. Whereas the F gene was relatively conserved between subgroups, a high degree of variation was observed in the extracellular domain of the G gene of the virus. The G protein identities between groups A and B were 45.1%–53.1% at the nucleotide level and 22.4%–27.6% at the amino acid level. These results provide evidence for the diversity of both surface glycoproteins of hMPV in Africa, which may be a prerequisite to understanding protective immunity against hMPV.https://wwwnc.cdc.gov/eid/article/11/7/05-0050_articleKeywords: molecular epidemiologyhuman metapneumovirusF geneG geneAfricagenotype |
| spellingShingle | Herbert P. Ludewick Yacine Abed Nadia van Niekerk Guy Boivin Keith P. Klugman Shabir A. Madhi Human Metapneumovirus Genetic Variability, South Africa Emerging Infectious Diseases Keywords: molecular epidemiology human metapneumovirus F gene G gene Africa genotype |
| title | Human Metapneumovirus Genetic Variability, South Africa |
| title_full | Human Metapneumovirus Genetic Variability, South Africa |
| title_fullStr | Human Metapneumovirus Genetic Variability, South Africa |
| title_full_unstemmed | Human Metapneumovirus Genetic Variability, South Africa |
| title_short | Human Metapneumovirus Genetic Variability, South Africa |
| title_sort | human metapneumovirus genetic variability south africa |
| topic | Keywords: molecular epidemiology human metapneumovirus F gene G gene Africa genotype |
| url | https://wwwnc.cdc.gov/eid/article/11/7/05-0050_article |
| work_keys_str_mv | AT herbertpludewick humanmetapneumovirusgeneticvariabilitysouthafrica AT yacineabed humanmetapneumovirusgeneticvariabilitysouthafrica AT nadiavanniekerk humanmetapneumovirusgeneticvariabilitysouthafrica AT guyboivin humanmetapneumovirusgeneticvariabilitysouthafrica AT keithpklugman humanmetapneumovirusgeneticvariabilitysouthafrica AT shabiramadhi humanmetapneumovirusgeneticvariabilitysouthafrica |