Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun Değerlendirilmesi
Aim: The most common side effects of terbinafine are gastrointestinal symptoms. Loss of taste and smell side effects are presented in a small number of case reports. We aimed to measure the effect of terbinafine on the sense of smell and the degree of change in the sense of smell in this study. Mate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Duzce University
2021-12-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/2028792 |
| _version_ | 1797668853540454400 |
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| author | Tuna Sezer Özge Uzun Yusuf Özgür Biçer Belgin Küçükyangöz Tekden Karapınar Mualla Polat |
| author_facet | Tuna Sezer Özge Uzun Yusuf Özgür Biçer Belgin Küçükyangöz Tekden Karapınar Mualla Polat |
| author_sort | Tuna Sezer |
| collection | DOAJ |
| description | Aim: The most common side effects of terbinafine are gastrointestinal symptoms. Loss of taste and smell side effects are presented in a small number of case reports. We aimed to measure the effect of terbinafine on the sense of smell and the degree of change in the sense of smell in this study.
Material and Methods: Odor identification test (OIT), odor threshold test (OTT), and odor discrimination test (ODT) were applied to the patients treated with terbinafine and the control group. It was applied with “Sniffin Sticks” test pens. Smell test was performed on the patient group just before the start of terbinafine treatment and at the end of 3 months of treatment.
Results: There was no statistical difference between the patient and control groups in terms of age (p=0.991) and gender (p=0.811). There was no statistical difference when the initial odor tests of the patient group and the control group were compared. The OIT value of the patient group was 10.15±1.43 at the beginning and 10.10±1.15 at the end of the treatment (p=0.743). The OTT values were 6.23±1.08 at the beginning and 6.21±0.85 at the end of the treatment (p=0.811). The ODT values were 9.71±1.44 at the beginning and 9.69±1.34 at the end of the treatment (p=0.767). There was no statistical difference in the results of the tests performed at the beginning and end of the treatment.
Conclusion: There was no adverse effect on the sense of smell associated with the use of systemic terbinafine treatment for 3 months. |
| first_indexed | 2024-03-11T20:35:32Z |
| format | Article |
| id | doaj.art-a389831606f844dca5ce40728302fdc9 |
| institution | Directory Open Access Journal |
| issn | 1307-671X |
| language | English |
| last_indexed | 2024-03-11T20:35:32Z |
| publishDate | 2021-12-01 |
| publisher | Duzce University |
| record_format | Article |
| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj.art-a389831606f844dca5ce40728302fdc92023-10-02T06:47:56ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2021-12-0123329429810.18678/dtfd.101017797Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun DeğerlendirilmesiTuna Sezer0Özge Uzun1Yusuf Özgür Biçer2Belgin Küçükyangöz3Tekden Karapınar4Mualla Polat5Izzet Baysal Devlet HastanesiİSTANBUL AREL ÜNİVERSİTESİBOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ, TIP FAKÜLTESİBOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ, TIP FAKÜLTESİBingöl Devlet hastanesiBOLU ABANT IZZET BAYSAL UNIVERSITY, SCHOOL OF MEDICINEAim: The most common side effects of terbinafine are gastrointestinal symptoms. Loss of taste and smell side effects are presented in a small number of case reports. We aimed to measure the effect of terbinafine on the sense of smell and the degree of change in the sense of smell in this study. Material and Methods: Odor identification test (OIT), odor threshold test (OTT), and odor discrimination test (ODT) were applied to the patients treated with terbinafine and the control group. It was applied with “Sniffin Sticks” test pens. Smell test was performed on the patient group just before the start of terbinafine treatment and at the end of 3 months of treatment. Results: There was no statistical difference between the patient and control groups in terms of age (p=0.991) and gender (p=0.811). There was no statistical difference when the initial odor tests of the patient group and the control group were compared. The OIT value of the patient group was 10.15±1.43 at the beginning and 10.10±1.15 at the end of the treatment (p=0.743). The OTT values were 6.23±1.08 at the beginning and 6.21±0.85 at the end of the treatment (p=0.811). The ODT values were 9.71±1.44 at the beginning and 9.69±1.34 at the end of the treatment (p=0.767). There was no statistical difference in the results of the tests performed at the beginning and end of the treatment. Conclusion: There was no adverse effect on the sense of smell associated with the use of systemic terbinafine treatment for 3 months.https://dergipark.org.tr/en/download/article-file/2028792terbinafinonikomikozsniffin’sticks testkokuterbinafineonychomycosissniffin’sticks testodor |
| spellingShingle | Tuna Sezer Özge Uzun Yusuf Özgür Biçer Belgin Küçükyangöz Tekden Karapınar Mualla Polat Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun Değerlendirilmesi Düzce Tıp Fakültesi Dergisi terbinafin onikomikoz sniffin’sticks test koku terbinafine onychomycosis sniffin’sticks test odor |
| title | Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun Değerlendirilmesi |
| title_full | Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun Değerlendirilmesi |
| title_fullStr | Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun Değerlendirilmesi |
| title_full_unstemmed | Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun Değerlendirilmesi |
| title_short | Terbinafin Tedavisi Alan Onikomikoz Hastalarında Koku Duyusunun Değerlendirilmesi |
| title_sort | terbinafin tedavisi alan onikomikoz hastalarinda koku duyusunun degerlendirilmesi |
| topic | terbinafin onikomikoz sniffin’sticks test koku terbinafine onychomycosis sniffin’sticks test odor |
| url | https://dergipark.org.tr/en/download/article-file/2028792 |
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