STUDY OF THE INFLUENCE OF HEREDITARY THROMBOPHILIES IN THE DEVELOPMENT OF VENOUS THROMBOSIS IN COMBAT INJURY
Introduction. Combat trauma is one of the factors that cause impaired hemostasis in the wounded. Currently, there is not enough information about the significance of hereditary thrombophilia in the development of venous thromboembolic complications in the wounded.Target. Study of the effect of polym...
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| Format: | Article |
| Language: | English |
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Ministry of Health of the Russian Federation, Irkutsk State Medical University
2023-09-01
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| Series: | Байкальский медицинский журнал |
| Subjects: | |
| Online Access: | https://www.bmjour.ru/jour/article/view/91 |
| _version_ | 1797370657860747264 |
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| author | Nikita Alexeyevich Varavin Diana Alexandrovna Bardakova Alexander Aleksandrovich Santakov |
| author_facet | Nikita Alexeyevich Varavin Diana Alexandrovna Bardakova Alexander Aleksandrovich Santakov |
| author_sort | Nikita Alexeyevich Varavin |
| collection | DOAJ |
| description | Introduction. Combat trauma is one of the factors that cause impaired hemostasis in the wounded. Currently, there is not enough information about the significance of hereditary thrombophilia in the development of venous thromboembolic complications in the wounded.Target. Study of the effect of polymorphism of the genes of the components of the hemostasis system on the development of venous thrombosis in the wounded with a combat injury.Materials and methods. The prospective study included young men (n=81) (mean age 36.0 ± 8.5 years) who received a combat wound and were treated at the Military Medical Academy. CM. Kirov. The subjects were divided into 2 groups: the main group included 40 patients (49.4%) who were diagnosed with venous thrombosis during treatment, the control group included 41 patients without signs of thrombosis (50.6%). The study of allelic polymorphism of genes associated with the process of thrombus formation was carried out using a real-time polymerase chain reaction based on the study of human DNA in peripheral blood material.Results. In a comparative analysis, no statistically significant differences were found in the frequency of occurrence of the studied genetic variants between the study group and the control group. When assessing the prevalence of polymorphisms in the MTHFR and MTRR genes, it was found that the combination of the MTHFR 677 CT and MTRR 66 GG genotypes is associated with an 8.5-fold increase in the risk of developing venous thromboembolic complications [OR=8.5; p=0.029].Conclusion. The analysis of the obtained results showed that, despite the high prevalence (the presence of prothrombogenic alleles of various genes was detected in 79 military personnel (97.5%)), it was not possible to establish a relationship between individual genetic variants and the risk of developing venous thrombosis in the studied group of wounded. At the same time, it has been shown that the combination of the MTHFR 677 CT and MTRR 66 GG genotypes is associated with a significant increase in the risk of thrombosis. |
| first_indexed | 2024-03-08T18:08:50Z |
| format | Article |
| id | doaj.art-a389c57f9a204dd5acad86cd71cb1fca |
| institution | Directory Open Access Journal |
| issn | 2949-0715 |
| language | English |
| last_indexed | 2024-03-08T18:08:50Z |
| publishDate | 2023-09-01 |
| publisher | Ministry of Health of the Russian Federation, Irkutsk State Medical University |
| record_format | Article |
| series | Байкальский медицинский журнал |
| spelling | doaj.art-a389c57f9a204dd5acad86cd71cb1fca2024-01-01T12:18:06ZengMinistry of Health of the Russian Federation, Irkutsk State Medical UniversityБайкальский медицинский журнал2949-07152023-09-0123373810.57256/2949-0715-2023-3-37-3854STUDY OF THE INFLUENCE OF HEREDITARY THROMBOPHILIES IN THE DEVELOPMENT OF VENOUS THROMBOSIS IN COMBAT INJURYNikita Alexeyevich Varavin0Diana Alexandrovna Bardakova1Alexander Aleksandrovich Santakov2ФГБВОУ ВО Военно-медицинской академии имени С.М. Кирова МО РФ, Санкт-ПетербургФГБВОУ ВО Военно-медицинской академии имени С.М. Кирова МО РФ, Санкт-ПетербургФГБВОУ ВО Военно-медицинской академии имени С.М. Кирова МО РФ, Санкт-ПетербургIntroduction. Combat trauma is one of the factors that cause impaired hemostasis in the wounded. Currently, there is not enough information about the significance of hereditary thrombophilia in the development of venous thromboembolic complications in the wounded.Target. Study of the effect of polymorphism of the genes of the components of the hemostasis system on the development of venous thrombosis in the wounded with a combat injury.Materials and methods. The prospective study included young men (n=81) (mean age 36.0 ± 8.5 years) who received a combat wound and were treated at the Military Medical Academy. CM. Kirov. The subjects were divided into 2 groups: the main group included 40 patients (49.4%) who were diagnosed with venous thrombosis during treatment, the control group included 41 patients without signs of thrombosis (50.6%). The study of allelic polymorphism of genes associated with the process of thrombus formation was carried out using a real-time polymerase chain reaction based on the study of human DNA in peripheral blood material.Results. In a comparative analysis, no statistically significant differences were found in the frequency of occurrence of the studied genetic variants between the study group and the control group. When assessing the prevalence of polymorphisms in the MTHFR and MTRR genes, it was found that the combination of the MTHFR 677 CT and MTRR 66 GG genotypes is associated with an 8.5-fold increase in the risk of developing venous thromboembolic complications [OR=8.5; p=0.029].Conclusion. The analysis of the obtained results showed that, despite the high prevalence (the presence of prothrombogenic alleles of various genes was detected in 79 military personnel (97.5%)), it was not possible to establish a relationship between individual genetic variants and the risk of developing venous thrombosis in the studied group of wounded. At the same time, it has been shown that the combination of the MTHFR 677 CT and MTRR 66 GG genotypes is associated with a significant increase in the risk of thrombosis.https://www.bmjour.ru/jour/article/view/91гены компонентов системы гемостазавенозный тромбозбоевая травма |
| spellingShingle | Nikita Alexeyevich Varavin Diana Alexandrovna Bardakova Alexander Aleksandrovich Santakov STUDY OF THE INFLUENCE OF HEREDITARY THROMBOPHILIES IN THE DEVELOPMENT OF VENOUS THROMBOSIS IN COMBAT INJURY Байкальский медицинский журнал гены компонентов системы гемостаза венозный тромбоз боевая травма |
| title | STUDY OF THE INFLUENCE OF HEREDITARY THROMBOPHILIES IN THE DEVELOPMENT OF VENOUS THROMBOSIS IN COMBAT INJURY |
| title_full | STUDY OF THE INFLUENCE OF HEREDITARY THROMBOPHILIES IN THE DEVELOPMENT OF VENOUS THROMBOSIS IN COMBAT INJURY |
| title_fullStr | STUDY OF THE INFLUENCE OF HEREDITARY THROMBOPHILIES IN THE DEVELOPMENT OF VENOUS THROMBOSIS IN COMBAT INJURY |
| title_full_unstemmed | STUDY OF THE INFLUENCE OF HEREDITARY THROMBOPHILIES IN THE DEVELOPMENT OF VENOUS THROMBOSIS IN COMBAT INJURY |
| title_short | STUDY OF THE INFLUENCE OF HEREDITARY THROMBOPHILIES IN THE DEVELOPMENT OF VENOUS THROMBOSIS IN COMBAT INJURY |
| title_sort | study of the influence of hereditary thrombophilies in the development of venous thrombosis in combat injury |
| topic | гены компонентов системы гемостаза венозный тромбоз боевая травма |
| url | https://www.bmjour.ru/jour/article/view/91 |
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