Pharmacokinetics and drug therapy in neonates
Neonates include both full term and preterm infants up to 28 days of age. The heterogeneity and rapid physiologic change of neonates affect all aspects of pharmacokinetics such as absorption, distribution, metabolism, and elimination. This feature should be considered in determining the dose and reg...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Emergency Medicine
2017-06-01
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| Series: | Pediatric Emergency Medicine Journal |
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| Online Access: | http://pemj.org/upload/pdf/pemj-2017-00059.pdf |
| _version_ | 1797852263645970432 |
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| author | Hye Jung Cho |
| author_facet | Hye Jung Cho |
| author_sort | Hye Jung Cho |
| collection | DOAJ |
| description | Neonates include both full term and preterm infants up to 28 days of age. The heterogeneity and rapid physiologic change of neonates affect all aspects of pharmacokinetics such as absorption, distribution, metabolism, and elimination. This feature should be considered in determining the dose and regimen of drug therapy in neonates. However, the research on the safety and efficacy of specific drugs is limited due to ethical and technical issues. This review article focuses on the neonatal pharmacokinetics and the rationales of drug therapy in neonates based on findings of previous studies and empirical evidence. |
| first_indexed | 2024-04-09T19:31:14Z |
| format | Article |
| id | doaj.art-a38b9c832c3a4e06974ac9df1e3e7f84 |
| institution | Directory Open Access Journal |
| issn | 2383-4897 2508-5506 |
| language | English |
| last_indexed | 2024-04-09T19:31:14Z |
| publishDate | 2017-06-01 |
| publisher | Korean Society of Pediatric Emergency Medicine |
| record_format | Article |
| series | Pediatric Emergency Medicine Journal |
| spelling | doaj.art-a38b9c832c3a4e06974ac9df1e3e7f842023-04-04T23:44:02ZengKorean Society of Pediatric Emergency MedicinePediatric Emergency Medicine Journal2383-48972508-55062017-06-014151110.22470/pemj.2017.0005944Pharmacokinetics and drug therapy in neonatesHye Jung Cho0Department of Pediatrics, Gachon University College of Medicine, Incheon, KoreaNeonates include both full term and preterm infants up to 28 days of age. The heterogeneity and rapid physiologic change of neonates affect all aspects of pharmacokinetics such as absorption, distribution, metabolism, and elimination. This feature should be considered in determining the dose and regimen of drug therapy in neonates. However, the research on the safety and efficacy of specific drugs is limited due to ethical and technical issues. This review article focuses on the neonatal pharmacokinetics and the rationales of drug therapy in neonates based on findings of previous studies and empirical evidence.http://pemj.org/upload/pdf/pemj-2017-00059.pdfbronchiolitisdrug administration routesdrug therapyinfantsnewbornpharmacokinetics |
| spellingShingle | Hye Jung Cho Pharmacokinetics and drug therapy in neonates Pediatric Emergency Medicine Journal bronchiolitis drug administration routes drug therapy infants newborn pharmacokinetics |
| title | Pharmacokinetics and drug therapy in neonates |
| title_full | Pharmacokinetics and drug therapy in neonates |
| title_fullStr | Pharmacokinetics and drug therapy in neonates |
| title_full_unstemmed | Pharmacokinetics and drug therapy in neonates |
| title_short | Pharmacokinetics and drug therapy in neonates |
| title_sort | pharmacokinetics and drug therapy in neonates |
| topic | bronchiolitis drug administration routes drug therapy infants newborn pharmacokinetics |
| url | http://pemj.org/upload/pdf/pemj-2017-00059.pdf |
| work_keys_str_mv | AT hyejungcho pharmacokineticsanddrugtherapyinneonates |