A mechanochemical approach to access the proline–proline diketopiperazine framework

A mechanochemical approach to access the proline–proline diketopiperazine framework

Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline–proline dipeptides under solvent-free conditions. A deprotection–cycl...

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Bibliographic Details
Main Authors: Nicolas Pétry, Hafid Benakki, Eric Clot, Pascal Retailleau, Farhate Guenoun, Fatima Asserar, Chakib Sekkat, Thomas-Xavier Métro, Jean Martinez, Frédéric Lamaty
Format: Article
Language:English
Published: Beilstein-Institut 2017-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
ball mill
DFT calculations
diketopiperazine
mechanochemistry
pyrrolidine
Online Access:https://doi.org/10.3762/bjoc.13.217

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