ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN “REAL LIFE” – SERIES OF CLINICAL CASES IN A ROMANIAN REFERENCE CENTER
Introduction. Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) represent a group of conditions evolving with necrotizing inflammation in small and medium-sized blood vessels. AAV are composed of GPA (granulomatosis with polyangiitis, former Wegener’s granulomatosis), MPA (micro...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2017-12-01
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| Series: | Romanian Journal of Rheumatology |
| Subjects: | |
| Online Access: | https://rjr.com.ro/articles/2017.4/RJR_2017_4_Art-05.pdf |
| _version_ | 1819136825000722432 |
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| author | Mihaela-Lavinia Popescu Denisa Predeteanu Andra Balanescu F. Berghea Sanziana Daia Andreea Borangiu C.L. Constantinescu Laura Groseanu Ruxandra Ionescu Daniela Opris-Belinski |
| author_facet | Mihaela-Lavinia Popescu Denisa Predeteanu Andra Balanescu F. Berghea Sanziana Daia Andreea Borangiu C.L. Constantinescu Laura Groseanu Ruxandra Ionescu Daniela Opris-Belinski |
| author_sort | Mihaela-Lavinia Popescu |
| collection | DOAJ |
| description | Introduction. Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) represent a group of conditions evolving with necrotizing inflammation in small and medium-sized blood vessels. AAV are composed of GPA (granulomatosis with polyangiitis, former Wegener’s granulomatosis), MPA (microscopic polyangiitis) and EGPA (eosinophilic granulomatosis with polyangiitis, former Churg-Strauss syndrome). AAV receive immunosuppressive therapy associated with a high risk of complications.
Objective. The aim of this study was to characterize a single center cohort of AAV patients regarding clinical, biological and therapeutic features.
Method. We realized a cross-sectional study by consequently enrolling all the patients registered with AAV diagnosis between 2009 and 2017 in Department of Rheumatology of “Sfânta Maria” Hospital. Demographic, diseaserelated and therapeutic-related parameters were collected. The data was extracted from the clinical files.
Results. The study sample included 26 cases, 15 females and 11 males: 20 patients GPA, 4 MPA and 2 cases EGPA. Mean age at the time of diagnosis was around 48 but 12 patients presented delays between age at the onset and age at the time of diagnosis (the mean delay was 2 years). The most frequent clinical manifestation identified where pulmonary, musculoskeletal and renal. 15 patients had a diagnostic biopsy performed. ANCA detection revealed 16 cases of c-ANCA and 7 cases of p-ANCA and 11 patients presented other positive serology. A combination of glucocorticoids and cyclophosphamide was used in most of the cases for remission-induction treatment and the same scheme was used for relapse cases. For maintenance phase a combination of glucocorticoids and azathioprine was preferred. 13 patients (50%) developed treatment related complications.
Conclusion. Most of the patients were diagnosed with GPA (20) and the least were diagnosed with EGPA (2). Biopsy was performed in 15 cases and it was mostly nasal. For remission-induction prevailed the combination of glucocorticoids and cyclophosphamide. Most treatment related complications were due to glucocorticoids administration. Osteoporosis was predominant. |
| first_indexed | 2024-12-22T10:41:08Z |
| format | Article |
| id | doaj.art-a391372ea1d447e8a950a6d1d806a959 |
| institution | Directory Open Access Journal |
| issn | 1843-0791 2069-6086 |
| language | English |
| last_indexed | 2024-12-22T10:41:08Z |
| publishDate | 2017-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Rheumatology |
| spelling | doaj.art-a391372ea1d447e8a950a6d1d806a9592022-12-21T18:29:01ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862017-12-0126416416810.37897/RJR.2017.4.5ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN “REAL LIFE” – SERIES OF CLINICAL CASES IN A ROMANIAN REFERENCE CENTERMihaela-Lavinia Popescu0Denisa Predeteanu1Andra Balanescu2F. Berghea3Sanziana Daia4Andreea Borangiu5C.L. Constantinescu6Laura Groseanu7Ruxandra Ionescu8Daniela Opris-Belinski9Clinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestClinical Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestIntroduction. Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) represent a group of conditions evolving with necrotizing inflammation in small and medium-sized blood vessels. AAV are composed of GPA (granulomatosis with polyangiitis, former Wegener’s granulomatosis), MPA (microscopic polyangiitis) and EGPA (eosinophilic granulomatosis with polyangiitis, former Churg-Strauss syndrome). AAV receive immunosuppressive therapy associated with a high risk of complications. Objective. The aim of this study was to characterize a single center cohort of AAV patients regarding clinical, biological and therapeutic features. Method. We realized a cross-sectional study by consequently enrolling all the patients registered with AAV diagnosis between 2009 and 2017 in Department of Rheumatology of “Sfânta Maria” Hospital. Demographic, diseaserelated and therapeutic-related parameters were collected. The data was extracted from the clinical files. Results. The study sample included 26 cases, 15 females and 11 males: 20 patients GPA, 4 MPA and 2 cases EGPA. Mean age at the time of diagnosis was around 48 but 12 patients presented delays between age at the onset and age at the time of diagnosis (the mean delay was 2 years). The most frequent clinical manifestation identified where pulmonary, musculoskeletal and renal. 15 patients had a diagnostic biopsy performed. ANCA detection revealed 16 cases of c-ANCA and 7 cases of p-ANCA and 11 patients presented other positive serology. A combination of glucocorticoids and cyclophosphamide was used in most of the cases for remission-induction treatment and the same scheme was used for relapse cases. For maintenance phase a combination of glucocorticoids and azathioprine was preferred. 13 patients (50%) developed treatment related complications. Conclusion. Most of the patients were diagnosed with GPA (20) and the least were diagnosed with EGPA (2). Biopsy was performed in 15 cases and it was mostly nasal. For remission-induction prevailed the combination of glucocorticoids and cyclophosphamide. Most treatment related complications were due to glucocorticoids administration. Osteoporosis was predominant.https://rjr.com.ro/articles/2017.4/RJR_2017_4_Art-05.pdfantineutrophil cytoplasmic antibody (anca)vasculitisglucocorticoids |
| spellingShingle | Mihaela-Lavinia Popescu Denisa Predeteanu Andra Balanescu F. Berghea Sanziana Daia Andreea Borangiu C.L. Constantinescu Laura Groseanu Ruxandra Ionescu Daniela Opris-Belinski ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN “REAL LIFE” – SERIES OF CLINICAL CASES IN A ROMANIAN REFERENCE CENTER Romanian Journal of Rheumatology antineutrophil cytoplasmic antibody (anca) vasculitis glucocorticoids |
| title | ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN “REAL LIFE” – SERIES OF CLINICAL CASES IN A ROMANIAN REFERENCE CENTER |
| title_full | ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN “REAL LIFE” – SERIES OF CLINICAL CASES IN A ROMANIAN REFERENCE CENTER |
| title_fullStr | ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN “REAL LIFE” – SERIES OF CLINICAL CASES IN A ROMANIAN REFERENCE CENTER |
| title_full_unstemmed | ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN “REAL LIFE” – SERIES OF CLINICAL CASES IN A ROMANIAN REFERENCE CENTER |
| title_short | ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN “REAL LIFE” – SERIES OF CLINICAL CASES IN A ROMANIAN REFERENCE CENTER |
| title_sort | antineutrophil cytoplasmic antibody associated vasculitis in real life series of clinical cases in a romanian reference center |
| topic | antineutrophil cytoplasmic antibody (anca) vasculitis glucocorticoids |
| url | https://rjr.com.ro/articles/2017.4/RJR_2017_4_Art-05.pdf |
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