Structural basis for MTA1c-mediated DNA N6-adenine methylation
DNA N6-adenine methylation (6 mA) plays a crucial role in epigenetic regulation in eukaryotes. Here, the authors determined nine crystal structures of the ciliates 6 mA methyltransferase complexes, providing the molecular basis for understanding the functions of 6 mA.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31060-6 |
| _version_ | 1828215537877909504 |
|---|---|
| author | Jiyun Chen Rong Hu Ying Chen Xiaofeng Lin Wenwen Xiang Hong Chen Canglin Yao Liang Liu |
| author_facet | Jiyun Chen Rong Hu Ying Chen Xiaofeng Lin Wenwen Xiang Hong Chen Canglin Yao Liang Liu |
| author_sort | Jiyun Chen |
| collection | DOAJ |
| description | DNA N6-adenine methylation (6 mA) plays a crucial role in epigenetic regulation in eukaryotes. Here, the authors determined nine crystal structures of the ciliates 6 mA methyltransferase complexes, providing the molecular basis for understanding the functions of 6 mA. |
| first_indexed | 2024-04-12T15:20:45Z |
| format | Article |
| id | doaj.art-a392f3d4fc164bcbb642938434e82890 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T15:20:45Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a392f3d4fc164bcbb642938434e828902022-12-22T03:27:27ZengNature PortfolioNature Communications2041-17232022-06-0113111510.1038/s41467-022-31060-6Structural basis for MTA1c-mediated DNA N6-adenine methylationJiyun Chen0Rong Hu1Ying Chen2Xiaofeng Lin3Wenwen Xiang4Hong Chen5Canglin Yao6Liang Liu7State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen UniversityDepartment of Biological Sciences, University of California, San DiegoState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen UniversityDNA N6-adenine methylation (6 mA) plays a crucial role in epigenetic regulation in eukaryotes. Here, the authors determined nine crystal structures of the ciliates 6 mA methyltransferase complexes, providing the molecular basis for understanding the functions of 6 mA.https://doi.org/10.1038/s41467-022-31060-6 |
| spellingShingle | Jiyun Chen Rong Hu Ying Chen Xiaofeng Lin Wenwen Xiang Hong Chen Canglin Yao Liang Liu Structural basis for MTA1c-mediated DNA N6-adenine methylation Nature Communications |
| title | Structural basis for MTA1c-mediated DNA N6-adenine methylation |
| title_full | Structural basis for MTA1c-mediated DNA N6-adenine methylation |
| title_fullStr | Structural basis for MTA1c-mediated DNA N6-adenine methylation |
| title_full_unstemmed | Structural basis for MTA1c-mediated DNA N6-adenine methylation |
| title_short | Structural basis for MTA1c-mediated DNA N6-adenine methylation |
| title_sort | structural basis for mta1c mediated dna n6 adenine methylation |
| url | https://doi.org/10.1038/s41467-022-31060-6 |
| work_keys_str_mv | AT jiyunchen structuralbasisformta1cmediateddnan6adeninemethylation AT ronghu structuralbasisformta1cmediateddnan6adeninemethylation AT yingchen structuralbasisformta1cmediateddnan6adeninemethylation AT xiaofenglin structuralbasisformta1cmediateddnan6adeninemethylation AT wenwenxiang structuralbasisformta1cmediateddnan6adeninemethylation AT hongchen structuralbasisformta1cmediateddnan6adeninemethylation AT canglinyao structuralbasisformta1cmediateddnan6adeninemethylation AT liangliu structuralbasisformta1cmediateddnan6adeninemethylation |