Blastocyst-endometrium interaction: intertwining a cytokine network
The successful implantation of the blastocyst depends on adequate interactions between the embryo and the uterus. The development of the embryo begins with the fertilized ovum, a single totipotent cell which undergoes mitosis and gives rise to a multicellular structure named blastocyst. At the same...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
2006-11-01
|
| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100001 |
| _version_ | 1811194169733939200 |
|---|---|
| author | W.A. Castro-Rendón J.F. Castro-Álvarez C. Guzmán-Martinez J.C. Bueno-Sanchez |
| author_facet | W.A. Castro-Rendón J.F. Castro-Álvarez C. Guzmán-Martinez J.C. Bueno-Sanchez |
| author_sort | W.A. Castro-Rendón |
| collection | DOAJ |
| description | The successful implantation of the blastocyst depends on adequate interactions between the embryo and the uterus. The development of the embryo begins with the fertilized ovum, a single totipotent cell which undergoes mitosis and gives rise to a multicellular structure named blastocyst. At the same time, increasing concentrations of ovarian steroid hormones initiate a complex signaling cascade that stimulates the differentiation of endometrial stromal cells to decidual cells, preparing the uterus to lodge the embryo. Studies in humans and in other mammals have shown that cytokines and growth factors are produced by the pre-implantation embryo and cells of the reproductive tract; however, the interactions between these factors that converge for successful implantation are not well understood. This review focuses on the actions of interleukin-1, leukemia inhibitory factor, epidermal growth factor, heparin-binding epidermal growth factor, and vascular endothelial growth factor, and on the network of their interactions leading to early embryo development, peri-implantatory endometrial changes, embryo implantation and trophoblast differentiation. We also propose therapeutical approaches based on current knowledge on cytokine interactions. |
| first_indexed | 2024-04-12T00:21:31Z |
| format | Article |
| id | doaj.art-a39631448f3e4a0b9f6abc90d55a9e6a |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-12T00:21:31Z |
| publishDate | 2006-11-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-a39631448f3e4a0b9f6abc90d55a9e6a2022-12-22T03:55:42ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2006-11-01391113731385Blastocyst-endometrium interaction: intertwining a cytokine networkW.A. Castro-RendónJ.F. Castro-ÁlvarezC. Guzmán-MartinezJ.C. Bueno-SanchezThe successful implantation of the blastocyst depends on adequate interactions between the embryo and the uterus. The development of the embryo begins with the fertilized ovum, a single totipotent cell which undergoes mitosis and gives rise to a multicellular structure named blastocyst. At the same time, increasing concentrations of ovarian steroid hormones initiate a complex signaling cascade that stimulates the differentiation of endometrial stromal cells to decidual cells, preparing the uterus to lodge the embryo. Studies in humans and in other mammals have shown that cytokines and growth factors are produced by the pre-implantation embryo and cells of the reproductive tract; however, the interactions between these factors that converge for successful implantation are not well understood. This review focuses on the actions of interleukin-1, leukemia inhibitory factor, epidermal growth factor, heparin-binding epidermal growth factor, and vascular endothelial growth factor, and on the network of their interactions leading to early embryo development, peri-implantatory endometrial changes, embryo implantation and trophoblast differentiation. We also propose therapeutical approaches based on current knowledge on cytokine interactions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100001Embryo implantationTrophoblastCytokinesProstaglandinsAspirin |
| spellingShingle | W.A. Castro-Rendón J.F. Castro-Álvarez C. Guzmán-Martinez J.C. Bueno-Sanchez Blastocyst-endometrium interaction: intertwining a cytokine network Brazilian Journal of Medical and Biological Research Embryo implantation Trophoblast Cytokines Prostaglandins Aspirin |
| title | Blastocyst-endometrium interaction: intertwining a cytokine network |
| title_full | Blastocyst-endometrium interaction: intertwining a cytokine network |
| title_fullStr | Blastocyst-endometrium interaction: intertwining a cytokine network |
| title_full_unstemmed | Blastocyst-endometrium interaction: intertwining a cytokine network |
| title_short | Blastocyst-endometrium interaction: intertwining a cytokine network |
| title_sort | blastocyst endometrium interaction intertwining a cytokine network |
| topic | Embryo implantation Trophoblast Cytokines Prostaglandins Aspirin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100001 |
| work_keys_str_mv | AT wacastrorendon blastocystendometriuminteractionintertwiningacytokinenetwork AT jfcastroalvarez blastocystendometriuminteractionintertwiningacytokinenetwork AT cguzmanmartinez blastocystendometriuminteractionintertwiningacytokinenetwork AT jcbuenosanchez blastocystendometriuminteractionintertwiningacytokinenetwork |