Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes
<p>Abstract</p> <p>Background</p> <p>Osteoprotegerin is a member of the tumor necrosis factor-related family and inhibits RANK stimulation of osteoclast formation as a soluble decoy receptor. The goal of this study was to determine the relationship of serum osteoprotege...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-01-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://www.cardiab.com/content/12/1/11 |
| _version_ | 1818116722323881984 |
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| author | Aoki Atsushi Murata Miho Asano Tomoko Ikoma Aki Sasaki Masami Saito Tomoyuki Otani Taeko Jinbo Sachimi Ikeda Nahoko Kawakami Masanobu Ishikawa San-e |
| author_facet | Aoki Atsushi Murata Miho Asano Tomoko Ikoma Aki Sasaki Masami Saito Tomoyuki Otani Taeko Jinbo Sachimi Ikeda Nahoko Kawakami Masanobu Ishikawa San-e |
| author_sort | Aoki Atsushi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Osteoprotegerin is a member of the tumor necrosis factor-related family and inhibits RANK stimulation of osteoclast formation as a soluble decoy receptor. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes.</p> <p>Methods</p> <p>The subjects were 124 patients with type 2 diabetes mellitus, including 88 males and 36 females with a mean (± SD) age of 65.6 ± 8.2 years old. Serum levels of osteoprotegerin, osteocalcin, fibroblast growth factor 23 (FGF23), 25-hydroxyvitamin D3 and adiponectin were measured by ELISA. Vascular calcification in the cervical artery was examined by ultrasound sonography. The subjects were divided into 4 quartiles depending on serum osteoprotegerin levels.</p> <p>Results</p> <p>Vascular calcification was significantly higher in the 4th quartile and significantly lower in the 1st quartile of serum osteoprotegerin levels, compared to other quartiles. There were no differences in serum osteoprotegerin and vascular calcification among patients with different stages of diabetic nephropathy, but serum FGF23 levels were elevated in those with stage 4 diabetic nephropathy. Simple regression analysis showed that serum osteoprotegerin levels had significant positive correlations with age, systolic blood pressure and serum adiponectin levels, and significant negative correlations with BMI and serum 25-hydroxyvitamin D3.</p> <p>Conclusions</p> <p>These findings suggest that elevated serum osteoprotegerin may be involved in vascular calcification independently of progression of diabetic nephropathy in patients with type 2 diabetes.</p> |
| first_indexed | 2024-12-11T04:27:02Z |
| format | Article |
| id | doaj.art-a397519090674ee39b84f53c8fe28fa8 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-11T04:27:02Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-a397519090674ee39b84f53c8fe28fa82022-12-22T01:20:58ZengBMCCardiovascular Diabetology1475-28402013-01-011211110.1186/1475-2840-12-11Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetesAoki AtsushiMurata MihoAsano TomokoIkoma AkiSasaki MasamiSaito TomoyukiOtani TaekoJinbo SachimiIkeda NahokoKawakami MasanobuIshikawa San-e<p>Abstract</p> <p>Background</p> <p>Osteoprotegerin is a member of the tumor necrosis factor-related family and inhibits RANK stimulation of osteoclast formation as a soluble decoy receptor. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes.</p> <p>Methods</p> <p>The subjects were 124 patients with type 2 diabetes mellitus, including 88 males and 36 females with a mean (± SD) age of 65.6 ± 8.2 years old. Serum levels of osteoprotegerin, osteocalcin, fibroblast growth factor 23 (FGF23), 25-hydroxyvitamin D3 and adiponectin were measured by ELISA. Vascular calcification in the cervical artery was examined by ultrasound sonography. The subjects were divided into 4 quartiles depending on serum osteoprotegerin levels.</p> <p>Results</p> <p>Vascular calcification was significantly higher in the 4th quartile and significantly lower in the 1st quartile of serum osteoprotegerin levels, compared to other quartiles. There were no differences in serum osteoprotegerin and vascular calcification among patients with different stages of diabetic nephropathy, but serum FGF23 levels were elevated in those with stage 4 diabetic nephropathy. Simple regression analysis showed that serum osteoprotegerin levels had significant positive correlations with age, systolic blood pressure and serum adiponectin levels, and significant negative correlations with BMI and serum 25-hydroxyvitamin D3.</p> <p>Conclusions</p> <p>These findings suggest that elevated serum osteoprotegerin may be involved in vascular calcification independently of progression of diabetic nephropathy in patients with type 2 diabetes.</p>http://www.cardiab.com/content/12/1/11OsteoprotegerinVascular calcificationAtherosclerosisType 2 diabetes mellitus |
| spellingShingle | Aoki Atsushi Murata Miho Asano Tomoko Ikoma Aki Sasaki Masami Saito Tomoyuki Otani Taeko Jinbo Sachimi Ikeda Nahoko Kawakami Masanobu Ishikawa San-e Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes Cardiovascular Diabetology Osteoprotegerin Vascular calcification Atherosclerosis Type 2 diabetes mellitus |
| title | Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes |
| title_full | Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes |
| title_fullStr | Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes |
| title_full_unstemmed | Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes |
| title_short | Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes |
| title_sort | association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes |
| topic | Osteoprotegerin Vascular calcification Atherosclerosis Type 2 diabetes mellitus |
| url | http://www.cardiab.com/content/12/1/11 |
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