Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors

Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors

OBJECTIVE: Endostatin is a potent endogenous inhibitor of angiogenesis. It is derived from the proteolytic cleavage of collagen XVIII, which is encoded by the COL18A1 gene. A polymorphic COL18A1 allele encoding the functional polymorphism p.D104N impairs the activity of endostatin, resulting in a de...

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Bibliographic Details
Main Authors: Beatriz Marinho de Paula Mariani, Ericka Barbosa Trarbach, Tamaya Castro Ribeiro, Maria Adelaide Albergaria Pereira, Berenice Bilharinho Mendonca, Maria Candida Barisson Villares Fragoso
Format: Article
Language:English
Published: Elsevier España 2012-01-01
Series:Clinics
Subjects:
Endostatin
Angiogenesis
p.D104N polymorphism
Adrenocortical tumor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000200002

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