Myosin light chain kinase () coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions
Sphingosine 1-phosphate (S1P) is a potent bioactive endogenous lipid that signals a rearrangement of the actin cytoskeleton via the regulation of non-muscle myosin light chain kinase isoform (nmMLCK). S1P induces critical nmMLCK Y 464 and Y 471 phosphorylation resulting in translocation of nmMLCK to...
Main Authors: | Ting Wang, Mary E. Brown, Gabriel T. Kelly, Sara M. Camp, Joseph B. Mascarenhas, Xiaoguang Sun, Steven M. Dudek, Joe G.N. Garcia |
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Format: | Article |
Language: | English |
Published: |
Wiley
2018-03-01
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Series: | Pulmonary Circulation |
Online Access: | https://doi.org/10.1177/2045894018764171 |
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