Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies
Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS), produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS can damage macromolecules such as proteins and lipids and leads to cell autophagy, apoptosis, and necrosis to the cells. Th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Brain Circulation |
| Subjects: | |
| Online Access: | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2016;volume=2;issue=4;spage=153;epage=163;aulast=Li |
| _version_ | 1828867929018466304 |
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| author | Wenjun Li Shaohua Yang |
| author_facet | Wenjun Li Shaohua Yang |
| author_sort | Wenjun Li |
| collection | DOAJ |
| description | Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS), produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS can damage macromolecules such as proteins and lipids and leads to cell autophagy, apoptosis, and necrosis to the cells. This review describes studies on the generation of ROS, its role in the pathogenesis of ischemic stroke, and recent development in therapeutic strategies in reducing oxidative stress after ischemic stroke. |
| first_indexed | 2024-12-13T05:21:04Z |
| format | Article |
| id | doaj.art-a39a7f8c663049188fec2dfb6d056658 |
| institution | Directory Open Access Journal |
| issn | 2455-4626 |
| language | English |
| last_indexed | 2024-12-13T05:21:04Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Brain Circulation |
| spelling | doaj.art-a39a7f8c663049188fec2dfb6d0566582022-12-21T23:58:19ZengWolters Kluwer Medknow PublicationsBrain Circulation2455-46262016-01-012415316310.4103/2394-8108.195279Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategiesWenjun LiShaohua YangExcessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS), produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS can damage macromolecules such as proteins and lipids and leads to cell autophagy, apoptosis, and necrosis to the cells. This review describes studies on the generation of ROS, its role in the pathogenesis of ischemic stroke, and recent development in therapeutic strategies in reducing oxidative stress after ischemic stroke.http://www.braincirculation.org/article.asp?issn=2394-8108;year=2016;volume=2;issue=4;spage=153;epage=163;aulast=LiIschemic strokemitochondriaoxidative stressreactive oxygen species |
| spellingShingle | Wenjun Li Shaohua Yang Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies Brain Circulation Ischemic stroke mitochondria oxidative stress reactive oxygen species |
| title | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
| title_full | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
| title_fullStr | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
| title_full_unstemmed | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
| title_short | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
| title_sort | targeting oxidative stress for the treatment of ischemic stroke upstream and downstream therapeutic strategies |
| topic | Ischemic stroke mitochondria oxidative stress reactive oxygen species |
| url | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2016;volume=2;issue=4;spage=153;epage=163;aulast=Li |
| work_keys_str_mv | AT wenjunli targetingoxidativestressforthetreatmentofischemicstrokeupstreamanddownstreamtherapeuticstrategies AT shaohuayang targetingoxidativestressforthetreatmentofischemicstrokeupstreamanddownstreamtherapeuticstrategies |