Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure
Aim. To study the impact of a polymorphic variant of the matrix metalloproteinase-3 (MMP-3) gene on the development and course of chronic heart failure (CHF) in patients with coronary heart disease. Subjects and methods. A total of 277 patients with New York Heart Association (NYHA) Functional Class...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2015-04-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31704 |
| _version_ | 1831752995870605312 |
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| author | A T Teplyakov E N Berezikova S N Shilov E V Grakova Yu Yu Torim A V Efremov I D Safronov M G Pustovetova R S Karpov |
| author_facet | A T Teplyakov E N Berezikova S N Shilov E V Grakova Yu Yu Torim A V Efremov I D Safronov M G Pustovetova R S Karpov |
| author_sort | A T Teplyakov |
| collection | DOAJ |
| description | Aim. To study the impact of a polymorphic variant of the matrix metalloproteinase-3 (MMP-3) gene on the development and course of chronic heart failure (CHF) in patients with coronary heart disease. Subjects and methods. A total of 277 patients with New York Heart Association (NYHA) Functional Class (FC) II—IV CHF were examined. MMP-3 –1171 5A/6A genetic polymorphism was studied by polymerase chain reaction. A control group included 136 patients (mean age 53.6±4.8 years) with no signs of cardiovascular diseases, as evidenced by the examination. Results. The frequency of the 5A allele and the 5A/5A genotype of the 1171 5A/6A polymorphic locus in the MMP-3 gene proved to be higher in the patients with CHF than that in the control group. Thus, the variability of the 5A allele (odds ratio (OR), 1.39; 95% confidence interval (CI): 1.033 to 1.869; p=0.03) and the 5A/5A genotype (OR, 2.15; 95% CI: 1.131 to 4.070; p=0.02) was associated with increased risk for CHF. There were significant differences in the frequency of MMP-3 alleles and genotypes in relation to FC of CHF. The frequency of the 5A/5A genotype was substantially higher in the patients with NYHA FC IV CHF than that in those with NYHA FC II CHF (32.8% versus 15.2%; р=0.039). The frequency of the 5A allele was significantly higher in the patients with NYHA FC IV CHF than that in those with NYHA FC II CHF (55.5% and 39.3%; respectively; р=0.019). Thus, the carriage of the 5A allele and the 5A/5A genotype of the 1171 5A/6A polymorphic locus in the MMP-3 gene is a risk factor of severe CHF. Conclusion. The determination of ММР-3 –1171 5A/6A polymorphism may be recommended for the early prediction of a risk for the development and severe course of CHF. |
| first_indexed | 2024-12-21T23:13:10Z |
| format | Article |
| id | doaj.art-a39a8638f4be4f669f7b68139117e01f |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T23:13:10Z |
| publishDate | 2015-04-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-a39a8638f4be4f669f7b68139117e01f2022-12-21T18:46:59Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422015-04-0187481228720Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failureA T TeplyakovE N BerezikovaS N ShilovE V GrakovaYu Yu TorimA V EfremovI D SafronovM G PustovetovaR S KarpovAim. To study the impact of a polymorphic variant of the matrix metalloproteinase-3 (MMP-3) gene on the development and course of chronic heart failure (CHF) in patients with coronary heart disease. Subjects and methods. A total of 277 patients with New York Heart Association (NYHA) Functional Class (FC) II—IV CHF were examined. MMP-3 –1171 5A/6A genetic polymorphism was studied by polymerase chain reaction. A control group included 136 patients (mean age 53.6±4.8 years) with no signs of cardiovascular diseases, as evidenced by the examination. Results. The frequency of the 5A allele and the 5A/5A genotype of the 1171 5A/6A polymorphic locus in the MMP-3 gene proved to be higher in the patients with CHF than that in the control group. Thus, the variability of the 5A allele (odds ratio (OR), 1.39; 95% confidence interval (CI): 1.033 to 1.869; p=0.03) and the 5A/5A genotype (OR, 2.15; 95% CI: 1.131 to 4.070; p=0.02) was associated with increased risk for CHF. There were significant differences in the frequency of MMP-3 alleles and genotypes in relation to FC of CHF. The frequency of the 5A/5A genotype was substantially higher in the patients with NYHA FC IV CHF than that in those with NYHA FC II CHF (32.8% versus 15.2%; р=0.039). The frequency of the 5A allele was significantly higher in the patients with NYHA FC IV CHF than that in those with NYHA FC II CHF (55.5% and 39.3%; respectively; р=0.019). Thus, the carriage of the 5A allele and the 5A/5A genotype of the 1171 5A/6A polymorphic locus in the MMP-3 gene is a risk factor of severe CHF. Conclusion. The determination of ММР-3 –1171 5A/6A polymorphism may be recommended for the early prediction of a risk for the development and severe course of CHF.https://ter-arkhiv.ru/0040-3660/article/view/31704heart failurecoronary heart diseasegenetic polymorphismmatrix metalloproteinase-3 |
| spellingShingle | A T Teplyakov E N Berezikova S N Shilov E V Grakova Yu Yu Torim A V Efremov I D Safronov M G Pustovetova R S Karpov Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure Терапевтический архив heart failure coronary heart disease genetic polymorphism matrix metalloproteinase-3 |
| title | Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure |
| title_full | Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure |
| title_fullStr | Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure |
| title_full_unstemmed | Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure |
| title_short | Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure |
| title_sort | assessment of the role of matrix metalloproteinase 2 gene polymorphism in the development of chronic heart failure |
| topic | heart failure coronary heart disease genetic polymorphism matrix metalloproteinase-3 |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31704 |
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