Precision Medicine: Disease Subtyping and Tailored Treatment
The genomics-based concept of precision medicine began to emerge following the completion of the Human Genome Project. In contrast to evidence-based medicine, precision medicine will allow doctors and scientists to tailor the treatment of different subpopulations of patients who differ in their susc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/15/3837 |
| _version_ | 1797587036399468544 |
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| author | Richard C. Wang Zhixiang Wang |
| author_facet | Richard C. Wang Zhixiang Wang |
| author_sort | Richard C. Wang |
| collection | DOAJ |
| description | The genomics-based concept of precision medicine began to emerge following the completion of the Human Genome Project. In contrast to evidence-based medicine, precision medicine will allow doctors and scientists to tailor the treatment of different subpopulations of patients who differ in their susceptibility to specific diseases or responsiveness to specific therapies. The current precision medicine model was proposed to precisely classify patients into subgroups sharing a common biological basis of diseases for more effective tailored treatment to achieve improved outcomes. Precision medicine has become a term that symbolizes the new age of medicine. In this review, we examine the history, development, and future perspective of precision medicine. We also discuss the concepts, principles, tools, and applications of precision medicine and related fields. In our view, for precision medicine to work, two essential objectives need to be achieved. First, diseases need to be classified into various subtypes. Second, targeted therapies must be available for each specific disease subtype. Therefore, we focused this review on the progress in meeting these two objectives. |
| first_indexed | 2024-03-11T00:30:36Z |
| format | Article |
| id | doaj.art-a39b4c7ba4a9435f897ceb71ad81ba2c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:36Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a39b4c7ba4a9435f897ceb71ad81ba2c2023-11-18T22:42:06ZengMDPI AGCancers2072-66942023-07-011515383710.3390/cancers15153837Precision Medicine: Disease Subtyping and Tailored TreatmentRichard C. Wang0Zhixiang Wang1Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Medical Genetics, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, AB T6J 5H4, CanadaThe genomics-based concept of precision medicine began to emerge following the completion of the Human Genome Project. In contrast to evidence-based medicine, precision medicine will allow doctors and scientists to tailor the treatment of different subpopulations of patients who differ in their susceptibility to specific diseases or responsiveness to specific therapies. The current precision medicine model was proposed to precisely classify patients into subgroups sharing a common biological basis of diseases for more effective tailored treatment to achieve improved outcomes. Precision medicine has become a term that symbolizes the new age of medicine. In this review, we examine the history, development, and future perspective of precision medicine. We also discuss the concepts, principles, tools, and applications of precision medicine and related fields. In our view, for precision medicine to work, two essential objectives need to be achieved. First, diseases need to be classified into various subtypes. Second, targeted therapies must be available for each specific disease subtype. Therefore, we focused this review on the progress in meeting these two objectives.https://www.mdpi.com/2072-6694/15/15/3837precision medicinesubtypingbiomarkersmultiomicstailored treatmenttargeted therapy |
| spellingShingle | Richard C. Wang Zhixiang Wang Precision Medicine: Disease Subtyping and Tailored Treatment Cancers precision medicine subtyping biomarkers multiomics tailored treatment targeted therapy |
| title | Precision Medicine: Disease Subtyping and Tailored Treatment |
| title_full | Precision Medicine: Disease Subtyping and Tailored Treatment |
| title_fullStr | Precision Medicine: Disease Subtyping and Tailored Treatment |
| title_full_unstemmed | Precision Medicine: Disease Subtyping and Tailored Treatment |
| title_short | Precision Medicine: Disease Subtyping and Tailored Treatment |
| title_sort | precision medicine disease subtyping and tailored treatment |
| topic | precision medicine subtyping biomarkers multiomics tailored treatment targeted therapy |
| url | https://www.mdpi.com/2072-6694/15/15/3837 |
| work_keys_str_mv | AT richardcwang precisionmedicinediseasesubtypingandtailoredtreatment AT zhixiangwang precisionmedicinediseasesubtypingandtailoredtreatment |