Association between brain structures and migraine: A bidirectional Mendelian randomization study
BackgroundAccumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it is still not clear whether the associations of brain structural alterations with migraine are likely to be causal, or could be explained by reverse cau...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1148458/full |
| _version_ | 1811160824206589952 |
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| author | Xiaoming Guo Xiaoming Guo Dingkun Wang Caidi Ying Yuan Hong |
| author_facet | Xiaoming Guo Xiaoming Guo Dingkun Wang Caidi Ying Yuan Hong |
| author_sort | Xiaoming Guo |
| collection | DOAJ |
| description | BackgroundAccumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it is still not clear whether the associations of brain structural alterations with migraine are likely to be causal, or could be explained by reverse causality confounding.MethodsWe carried on a bidirectional Mendelian randomization analysis in order to identify the causal relationship between brain structures and migraine risk. Summary-level data and independent variants used as instruments came from large genome-wide association studies of total surface area and average thickness of cortex (33,992 participants), gray matter volume (8,428 participants), white matter hyperintensities (50,970 participants), hippocampal volume (33,536 participants), and migraine (102,084 cases and 771,257 controls).ResultsWe identified suggestive associations of the decreased surface area (OR = 0.85; 95% CI, 0.75–0.96; P = 0.007), and decreased hippocampal volume (OR = 0.74; 95% CI, 0.55–1.00; P = 0.047) with higher migraine risk. We did not find any significant association of gray matter volume, cortical thickness, or white matter hyperintensities with migraine. No evidence supporting the significant association was found in the reverse MR analysis.ConclusionWe provided suggestive evidence that surface area and hippocampal volume are causally associated with migraine risk. |
| first_indexed | 2024-04-10T06:04:07Z |
| format | Article |
| id | doaj.art-a39b961d707e48b4b846c0f7acdfcaaf |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T06:04:07Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-a39b961d707e48b4b846c0f7acdfcaaf2023-03-03T05:20:19ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-03-011710.3389/fnins.2023.11484581148458Association between brain structures and migraine: A bidirectional Mendelian randomization studyXiaoming Guo0Xiaoming Guo1Dingkun Wang2Caidi Ying3Yuan Hong4Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurosurgery, Tongde Hospital of Zhejiang Province, Hangzhou, ChinaDepartment of Neurosurgery, Tongde Hospital of Zhejiang Province, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaBackgroundAccumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it is still not clear whether the associations of brain structural alterations with migraine are likely to be causal, or could be explained by reverse causality confounding.MethodsWe carried on a bidirectional Mendelian randomization analysis in order to identify the causal relationship between brain structures and migraine risk. Summary-level data and independent variants used as instruments came from large genome-wide association studies of total surface area and average thickness of cortex (33,992 participants), gray matter volume (8,428 participants), white matter hyperintensities (50,970 participants), hippocampal volume (33,536 participants), and migraine (102,084 cases and 771,257 controls).ResultsWe identified suggestive associations of the decreased surface area (OR = 0.85; 95% CI, 0.75–0.96; P = 0.007), and decreased hippocampal volume (OR = 0.74; 95% CI, 0.55–1.00; P = 0.047) with higher migraine risk. We did not find any significant association of gray matter volume, cortical thickness, or white matter hyperintensities with migraine. No evidence supporting the significant association was found in the reverse MR analysis.ConclusionWe provided suggestive evidence that surface area and hippocampal volume are causally associated with migraine risk.https://www.frontiersin.org/articles/10.3389/fnins.2023.1148458/fullbrain structureNeuroImageMendelian randomizationmigrainecortex |
| spellingShingle | Xiaoming Guo Xiaoming Guo Dingkun Wang Caidi Ying Yuan Hong Association between brain structures and migraine: A bidirectional Mendelian randomization study Frontiers in Neuroscience brain structure NeuroImage Mendelian randomization migraine cortex |
| title | Association between brain structures and migraine: A bidirectional Mendelian randomization study |
| title_full | Association between brain structures and migraine: A bidirectional Mendelian randomization study |
| title_fullStr | Association between brain structures and migraine: A bidirectional Mendelian randomization study |
| title_full_unstemmed | Association between brain structures and migraine: A bidirectional Mendelian randomization study |
| title_short | Association between brain structures and migraine: A bidirectional Mendelian randomization study |
| title_sort | association between brain structures and migraine a bidirectional mendelian randomization study |
| topic | brain structure NeuroImage Mendelian randomization migraine cortex |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1148458/full |
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