A critical perspective on updating drug memories through the integration of memory editing and brain stimulation
Addiction is a persistent, recurring condition characterized by repeated relapses despite the desire to control drug use or maintain sobriety. The attainment of abstinence is hindered by persistent maladaptive drug-associated memories, which drive drug-seeking and use behavior. This article examines...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1161879/full |
| _version_ | 1797847240397553664 |
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| author | Xavier Noël Xavier Noël |
| author_facet | Xavier Noël Xavier Noël |
| author_sort | Xavier Noël |
| collection | DOAJ |
| description | Addiction is a persistent, recurring condition characterized by repeated relapses despite the desire to control drug use or maintain sobriety. The attainment of abstinence is hindered by persistent maladaptive drug-associated memories, which drive drug-seeking and use behavior. This article examines the preliminary evidence supporting the combination of non-invasive brain stimulation (NIBS) techniques and memory editing (or reconsolidation) interventions as add-on forms of treatment for individuals with substance-related disorders (SUD). Studies have shown that NIBS can modestly reduce drug use and craving through improved cognitive control or other undetermined reasons. Memory reconsolidation, a process by which a previously consolidated memory trace can be made labile again, can potentially erase or significantly weaken SUD memories underpinning craving and the propensity for relapse. This approach conveys enthusiasm while also emphasizing the importance of managing boundary conditions and null results for interventions found on fear memory reconsolidation. Recent studies, which align with the state-dependency and activity-selectivity hypotheses, have shown that the combination of NIBS and behavioral interventions holds promise for treating SUD by reducing self-reported and physiological aspects of craving. Effective long-term outcomes for this procedure require better identification of critical memories, a deeper understanding of the brain mechanisms underlying SUD and memory reconsolidation and overcoming any boundary conditions of destabilized memories. This will enable the procedure to be personalized to the unique needs of individual patients. |
| first_indexed | 2024-04-09T18:08:07Z |
| format | Article |
| id | doaj.art-a39c1114a9bd47769db007f23d3313fc |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T18:08:07Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a39c1114a9bd47769db007f23d3313fc2023-04-14T05:05:15ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-04-011410.3389/fpsyt.2023.11618791161879A critical perspective on updating drug memories through the integration of memory editing and brain stimulationXavier Noël0Xavier Noël1Laboratoire de Psychologie Médicale et d’Addictologie, Faculty of Medicine, Université Libre de Bruxelles (ULB), Brussels, BelgiumNeuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Brussels, BelgiumAddiction is a persistent, recurring condition characterized by repeated relapses despite the desire to control drug use or maintain sobriety. The attainment of abstinence is hindered by persistent maladaptive drug-associated memories, which drive drug-seeking and use behavior. This article examines the preliminary evidence supporting the combination of non-invasive brain stimulation (NIBS) techniques and memory editing (or reconsolidation) interventions as add-on forms of treatment for individuals with substance-related disorders (SUD). Studies have shown that NIBS can modestly reduce drug use and craving through improved cognitive control or other undetermined reasons. Memory reconsolidation, a process by which a previously consolidated memory trace can be made labile again, can potentially erase or significantly weaken SUD memories underpinning craving and the propensity for relapse. This approach conveys enthusiasm while also emphasizing the importance of managing boundary conditions and null results for interventions found on fear memory reconsolidation. Recent studies, which align with the state-dependency and activity-selectivity hypotheses, have shown that the combination of NIBS and behavioral interventions holds promise for treating SUD by reducing self-reported and physiological aspects of craving. Effective long-term outcomes for this procedure require better identification of critical memories, a deeper understanding of the brain mechanisms underlying SUD and memory reconsolidation and overcoming any boundary conditions of destabilized memories. This will enable the procedure to be personalized to the unique needs of individual patients.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1161879/fulladdictionmemory reconsolidationnon-invasive brain stimulationmemory editingsubstance use disorders |
| spellingShingle | Xavier Noël Xavier Noël A critical perspective on updating drug memories through the integration of memory editing and brain stimulation Frontiers in Psychiatry addiction memory reconsolidation non-invasive brain stimulation memory editing substance use disorders |
| title | A critical perspective on updating drug memories through the integration of memory editing and brain stimulation |
| title_full | A critical perspective on updating drug memories through the integration of memory editing and brain stimulation |
| title_fullStr | A critical perspective on updating drug memories through the integration of memory editing and brain stimulation |
| title_full_unstemmed | A critical perspective on updating drug memories through the integration of memory editing and brain stimulation |
| title_short | A critical perspective on updating drug memories through the integration of memory editing and brain stimulation |
| title_sort | critical perspective on updating drug memories through the integration of memory editing and brain stimulation |
| topic | addiction memory reconsolidation non-invasive brain stimulation memory editing substance use disorders |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1161879/full |
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