Serotonina plaquetária como marcador biológico de autismo.
Platelet levels of serotonin were determined by a quantitative direct radioimmunoassay, in a group of autistic patients and a control group. Thirty six autistic patients (28 males and 8 females), all with severe mental retardation, and a group of 23 matched controls, were studied. The serotonin leve...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
1997-12-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2522 |
| Summary: | Platelet levels of serotonin were determined by a quantitative direct radioimmunoassay, in a group of autistic patients and a control group. Thirty six autistic patients (28 males and 8 females), all with severe mental retardation, and a group of 23 matched controls, were studied. The serotonin levels in autistic patients (mean +/- SD) (88.37 mmol/dl +/- 40.38) were significantly higher that in the control group (49.54 mmol/dl +/- 16.49). There were no significant differences in levels between the sexes and age groups among subjects in the patient and the control groups. We detected a hyperserotoninaemia in 70% of the autistic patients. We also discuss correlations between serotonin levels in our patients with known aetiologies and levels quoted in the literature and propose RIA to be used as a quick, easy and reliable method for the analysis of large numbers of samples. |
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| ISSN: | 0870-399X 1646-0758 |