Serotonina plaquetária como marcador biológico de autismo.
Platelet levels of serotonin were determined by a quantitative direct radioimmunoassay, in a group of autistic patients and a control group. Thirty six autistic patients (28 males and 8 females), all with severe mental retardation, and a group of 23 matched controls, were studied. The serotonin leve...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
1997-12-01
|
| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2522 |
| _version_ | 1828340949734916096 |
|---|---|
| author | P Q Levy M P Bicho |
| author_facet | P Q Levy M P Bicho |
| author_sort | P Q Levy |
| collection | DOAJ |
| description | Platelet levels of serotonin were determined by a quantitative direct radioimmunoassay, in a group of autistic patients and a control group. Thirty six autistic patients (28 males and 8 females), all with severe mental retardation, and a group of 23 matched controls, were studied. The serotonin levels in autistic patients (mean +/- SD) (88.37 mmol/dl +/- 40.38) were significantly higher that in the control group (49.54 mmol/dl +/- 16.49). There were no significant differences in levels between the sexes and age groups among subjects in the patient and the control groups. We detected a hyperserotoninaemia in 70% of the autistic patients. We also discuss correlations between serotonin levels in our patients with known aetiologies and levels quoted in the literature and propose RIA to be used as a quick, easy and reliable method for the analysis of large numbers of samples. |
| first_indexed | 2024-04-13T23:04:18Z |
| format | Article |
| id | doaj.art-a39c5d1f583e4ddaa344ae21e14daa09 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-13T23:04:18Z |
| publishDate | 1997-12-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-a39c5d1f583e4ddaa344ae21e14daa092022-12-22T02:25:43ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581997-12-01101210.20344/amp.2522Serotonina plaquetária como marcador biológico de autismo.P Q Levy0M P BichoLaboratório de Genética, Faculdade de Medicina de Lisboa, Universidade de Lisboa.Platelet levels of serotonin were determined by a quantitative direct radioimmunoassay, in a group of autistic patients and a control group. Thirty six autistic patients (28 males and 8 females), all with severe mental retardation, and a group of 23 matched controls, were studied. The serotonin levels in autistic patients (mean +/- SD) (88.37 mmol/dl +/- 40.38) were significantly higher that in the control group (49.54 mmol/dl +/- 16.49). There were no significant differences in levels between the sexes and age groups among subjects in the patient and the control groups. We detected a hyperserotoninaemia in 70% of the autistic patients. We also discuss correlations between serotonin levels in our patients with known aetiologies and levels quoted in the literature and propose RIA to be used as a quick, easy and reliable method for the analysis of large numbers of samples.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2522 |
| spellingShingle | P Q Levy M P Bicho Serotonina plaquetária como marcador biológico de autismo. Acta Médica Portuguesa |
| title | Serotonina plaquetária como marcador biológico de autismo. |
| title_full | Serotonina plaquetária como marcador biológico de autismo. |
| title_fullStr | Serotonina plaquetária como marcador biológico de autismo. |
| title_full_unstemmed | Serotonina plaquetária como marcador biológico de autismo. |
| title_short | Serotonina plaquetária como marcador biológico de autismo. |
| title_sort | serotonina plaquetaria como marcador biologico de autismo |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2522 |
| work_keys_str_mv | AT pqlevy serotoninaplaquetariacomomarcadorbiologicodeautismo AT mpbicho serotoninaplaquetariacomomarcadorbiologicodeautismo |