The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis
One of the negative effects of ionizing radiation is the alteration of cellular signaling pathways which lead to carcinogenesis and tumorigenesis. In this review, we discussed the impacts of ionizing radiation on cells and cellular signaling pathways. In this regard, exposure to radiation can direct...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Zabol University of Medical sciences
2018-12-01
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| Series: | International Journal of Basic Science in Medicine |
| Subjects: | |
| Online Access: | http://ijbsm.zbmu.ac.ir/PDF/ijbsm-12299 |
| _version_ | 1828397163532517376 |
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| author | Sakine Rezaie Kahkhaie Khadije Rezaie Keikhaie |
| author_facet | Sakine Rezaie Kahkhaie Khadije Rezaie Keikhaie |
| author_sort | Sakine Rezaie Kahkhaie |
| collection | DOAJ |
| description | One of the negative effects of ionizing radiation is the alteration of cellular signaling pathways which lead to carcinogenesis and tumorigenesis. In this review, we discussed the impacts of ionizing radiation on cells and cellular signaling pathways. In this regard, exposure to radiation can directly or indirectly alter cellular signaling pathways. Remarkably, irradiated cells release special mediators into cellular matrix, aberrating cell-cell and cell-environment interactions. Most notably, these mediators include nitric oxide (NO), reactive oxygen species (ROS), and cell growth factors which contribute to cellular interactions between irradiated cells and their neighbor cells, a phenomenon known as radiation-induced bystander effect. DNA molecule is the most important cellular compartment damaged by ionizing radiation. On the other hand, the ability of irradiated cells to repair the damaged DNA is very low. Therefore, DNA alternations are passed to the next generations, and ultimately lead to carcinogenesis. The study of ionizing radiations and their impacts on biological systems is of remarkable importance to divulge their impacts on cellular signaling pathways. |
| first_indexed | 2024-12-10T08:41:50Z |
| format | Article |
| id | doaj.art-a39cde3a718e4dde804af090b8aff164 |
| institution | Directory Open Access Journal |
| issn | 2476-664X |
| language | English |
| last_indexed | 2024-12-10T08:41:50Z |
| publishDate | 2018-12-01 |
| publisher | Zabol University of Medical sciences |
| record_format | Article |
| series | International Journal of Basic Science in Medicine |
| spelling | doaj.art-a39cde3a718e4dde804af090b8aff1642022-12-22T01:55:50ZengZabol University of Medical sciencesInternational Journal of Basic Science in Medicine2476-664X2018-12-013414715310.15171/ijbsm.2018.26ijbsm-12299The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and CarcinogenesisSakine Rezaie Kahkhaie0Khadije Rezaie Keikhaie1Department of Physics, University of Zabol, Zabol, IranDepartment of Obstetrics and Gynecology, Faculty of Medicine, Pre-neonatology Fellowship, Zabol University of Medical Sciences, Zabol, IranOne of the negative effects of ionizing radiation is the alteration of cellular signaling pathways which lead to carcinogenesis and tumorigenesis. In this review, we discussed the impacts of ionizing radiation on cells and cellular signaling pathways. In this regard, exposure to radiation can directly or indirectly alter cellular signaling pathways. Remarkably, irradiated cells release special mediators into cellular matrix, aberrating cell-cell and cell-environment interactions. Most notably, these mediators include nitric oxide (NO), reactive oxygen species (ROS), and cell growth factors which contribute to cellular interactions between irradiated cells and their neighbor cells, a phenomenon known as radiation-induced bystander effect. DNA molecule is the most important cellular compartment damaged by ionizing radiation. On the other hand, the ability of irradiated cells to repair the damaged DNA is very low. Therefore, DNA alternations are passed to the next generations, and ultimately lead to carcinogenesis. The study of ionizing radiations and their impacts on biological systems is of remarkable importance to divulge their impacts on cellular signaling pathways.http://ijbsm.zbmu.ac.ir/PDF/ijbsm-12299PhysicsIonizing radiationCellular signaling pathwaysTumorigenesisCarcinogenesis |
| spellingShingle | Sakine Rezaie Kahkhaie Khadije Rezaie Keikhaie The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis International Journal of Basic Science in Medicine Physics Ionizing radiation Cellular signaling pathways Tumorigenesis Carcinogenesis |
| title | The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis |
| title_full | The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis |
| title_fullStr | The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis |
| title_full_unstemmed | The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis |
| title_short | The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis |
| title_sort | role of ionizing radiation in cellular signaling pathways mutagenesis and carcinogenesis |
| topic | Physics Ionizing radiation Cellular signaling pathways Tumorigenesis Carcinogenesis |
| url | http://ijbsm.zbmu.ac.ir/PDF/ijbsm-12299 |
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