Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria

Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria

Abstract Background Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control. One such gene drive involves the dsxF CRISPRh transgene encoding (i) hCas9 endonuclease, (ii) T1 guide RNA (gRNA) targeting the doublesex...

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Bibliographic Details
Main Authors: Alima Qureshi, John B. Connolly
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Malaria Journal
Subjects:
Population suppression
Gene drive
Environmental risk assessment (ERA)
Genetically modified mosquitoes (GMM)
CRISPR
Cas9
Online Access:https://doi.org/10.1186/s12936-023-04665-5

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