HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity
Background: Inhibition of histone deacetylase (HDAC) was reported to suppress cardiac hypertrophy and fibrosis in various hypertrophic animal models. However, the HDAC expression profile and HDAC enzyme activity have not yet been investigated in DOCA-salt hypertensive rats. Methods: Unilaterally nep...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2013-07-01
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| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/350148 |
| _version_ | 1828787664874110976 |
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| author | Hae Jin Kee Eun Hui Bae Sangha Park Ko Eun Lee Sang Heon Suh Soo Wan Kim Myung Ho Jeong |
| author_facet | Hae Jin Kee Eun Hui Bae Sangha Park Ko Eun Lee Sang Heon Suh Soo Wan Kim Myung Ho Jeong |
| author_sort | Hae Jin Kee |
| collection | DOAJ |
| description | Background: Inhibition of histone deacetylase (HDAC) was reported to suppress cardiac hypertrophy and fibrosis in various hypertrophic animal models. However, the HDAC expression profile and HDAC enzyme activity have not yet been investigated in DOCA-salt hypertensive rats. Methods: Unilaterally nephrectomized rats were implanted with DOCA strips. DOCA-salt rats then received a control diet with vehicle or valproate. We measured the expression of cardiac hypertrophic markers, class I HDACs, class II HDACs, fibrosis, and HDAC enzyme activity. Results: Here we report that sodium valproate inhibits the cardiac hypertrophy accompanied by fibrosis in the heart of chronic hypertensive rats. We show that expression of GATA6 and HDAC6 is upregulated in DOCA-salt hypertension. In addition, HDAC6 and HDAC8 enzyme activity is attenuated by sodium valproate. Conclusion: These results suggest that a novel HDAC6- and HDAC8-selective inhibitor is needed to treat or prevent pathological cardiac hypertrophy. |
| first_indexed | 2024-12-12T00:36:40Z |
| format | Article |
| id | doaj.art-a39d4f295fe146c0a06aa22e6352054c |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-12T00:36:40Z |
| publishDate | 2013-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-a39d4f295fe146c0a06aa22e6352054c2022-12-22T00:44:21ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432013-07-01374-522923910.1159/000350148350148HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme ActivityHae Jin KeeEun Hui BaeSangha ParkKo Eun LeeSang Heon SuhSoo Wan KimMyung Ho JeongBackground: Inhibition of histone deacetylase (HDAC) was reported to suppress cardiac hypertrophy and fibrosis in various hypertrophic animal models. However, the HDAC expression profile and HDAC enzyme activity have not yet been investigated in DOCA-salt hypertensive rats. Methods: Unilaterally nephrectomized rats were implanted with DOCA strips. DOCA-salt rats then received a control diet with vehicle or valproate. We measured the expression of cardiac hypertrophic markers, class I HDACs, class II HDACs, fibrosis, and HDAC enzyme activity. Results: Here we report that sodium valproate inhibits the cardiac hypertrophy accompanied by fibrosis in the heart of chronic hypertensive rats. We show that expression of GATA6 and HDAC6 is upregulated in DOCA-salt hypertension. In addition, HDAC6 and HDAC8 enzyme activity is attenuated by sodium valproate. Conclusion: These results suggest that a novel HDAC6- and HDAC8-selective inhibitor is needed to treat or prevent pathological cardiac hypertrophy.http://www.karger.com/Article/FullText/350148GATA6HDAC enzyme activityCardiac hypertrophyDOCA-salt hypertensive ratsHistone deacetylase inhibitor |
| spellingShingle | Hae Jin Kee Eun Hui Bae Sangha Park Ko Eun Lee Sang Heon Suh Soo Wan Kim Myung Ho Jeong HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity Kidney & Blood Pressure Research GATA6 HDAC enzyme activity Cardiac hypertrophy DOCA-salt hypertensive rats Histone deacetylase inhibitor |
| title | HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity |
| title_full | HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity |
| title_fullStr | HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity |
| title_full_unstemmed | HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity |
| title_short | HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity |
| title_sort | hdac inhibition suppresses cardiac hypertrophy and fibrosis in doca salt hypertensive rats via regulation of hdac6 hdac8 enzyme activity |
| topic | GATA6 HDAC enzyme activity Cardiac hypertrophy DOCA-salt hypertensive rats Histone deacetylase inhibitor |
| url | http://www.karger.com/Article/FullText/350148 |
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