Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression
Barrett’s esophagus is a pre-malignant condition that can progress to esophageal cancer. Here, the authors carry out whole genome sequencing of samples from patients who did or did not progress to cancer and find that mutations in many genes occur regardless of progression status, but also find feat...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29767-7 |
| _version_ | 1818006575861727232 |
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| author | Thomas G. Paulson Patricia C. Galipeau Kenji M. Oman Carissa A. Sanchez Mary K. Kuhner Lucian P. Smith Kevin Hadi Minita Shah Kanika Arora Jennifer Shelton Molly Johnson Andre Corvelo Carlo C. Maley Xiaotong Yao Rashesh Sanghvi Elisa Venturini Anne-Katrin Emde Benjamin Hubert Marcin Imielinski Nicolas Robine Brian J. Reid Xiaohong Li |
| author_facet | Thomas G. Paulson Patricia C. Galipeau Kenji M. Oman Carissa A. Sanchez Mary K. Kuhner Lucian P. Smith Kevin Hadi Minita Shah Kanika Arora Jennifer Shelton Molly Johnson Andre Corvelo Carlo C. Maley Xiaotong Yao Rashesh Sanghvi Elisa Venturini Anne-Katrin Emde Benjamin Hubert Marcin Imielinski Nicolas Robine Brian J. Reid Xiaohong Li |
| author_sort | Thomas G. Paulson |
| collection | DOAJ |
| description | Barrett’s esophagus is a pre-malignant condition that can progress to esophageal cancer. Here, the authors carry out whole genome sequencing of samples from patients who did or did not progress to cancer and find that mutations in many genes occur regardless of progression status, but also find features associated with progressive disease. |
| first_indexed | 2024-04-14T05:02:51Z |
| format | Article |
| id | doaj.art-a39d500ac4374fad8c2ae054c840d6f0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T05:02:51Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a39d500ac4374fad8c2ae054c840d6f02022-12-22T02:10:51ZengNature PortfolioNature Communications2041-17232022-04-0113111710.1038/s41467-022-29767-7Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progressionThomas G. Paulson0Patricia C. Galipeau1Kenji M. Oman2Carissa A. Sanchez3Mary K. Kuhner4Lucian P. Smith5Kevin Hadi6Minita Shah7Kanika Arora8Jennifer Shelton9Molly Johnson10Andre Corvelo11Carlo C. Maley12Xiaotong Yao13Rashesh Sanghvi14Elisa Venturini15Anne-Katrin Emde16Benjamin Hubert17Marcin Imielinski18Nicolas Robine19Brian J. Reid20Xiaohong Li21Division of Human Biology, Fred Hutchinson Cancer Research CenterDivision of Human Biology, Fred Hutchinson Cancer Research CenterDivision of Human Biology, Fred Hutchinson Cancer Research CenterDivision of Human Biology, Fred Hutchinson Cancer Research CenterDepartment of Genome Sciences, University of WashingtonDepartment of Genome Sciences, University of WashingtonNew York Genome Center (NYGC)New York Genome Center (NYGC)New York Genome Center (NYGC)New York Genome Center (NYGC)New York Genome Center (NYGC)New York Genome Center (NYGC)Arizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences, Arizona State UniversityNew York Genome Center (NYGC)New York Genome Center (NYGC)New York Genome Center (NYGC)Variant BioNew York Genome Center (NYGC)New York Genome Center (NYGC)New York Genome Center (NYGC)Division of Human Biology, Fred Hutchinson Cancer Research CenterDivision of Human Biology, Fred Hutchinson Cancer Research CenterBarrett’s esophagus is a pre-malignant condition that can progress to esophageal cancer. Here, the authors carry out whole genome sequencing of samples from patients who did or did not progress to cancer and find that mutations in many genes occur regardless of progression status, but also find features associated with progressive disease.https://doi.org/10.1038/s41467-022-29767-7 |
| spellingShingle | Thomas G. Paulson Patricia C. Galipeau Kenji M. Oman Carissa A. Sanchez Mary K. Kuhner Lucian P. Smith Kevin Hadi Minita Shah Kanika Arora Jennifer Shelton Molly Johnson Andre Corvelo Carlo C. Maley Xiaotong Yao Rashesh Sanghvi Elisa Venturini Anne-Katrin Emde Benjamin Hubert Marcin Imielinski Nicolas Robine Brian J. Reid Xiaohong Li Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression Nature Communications |
| title | Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression |
| title_full | Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression |
| title_fullStr | Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression |
| title_full_unstemmed | Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression |
| title_short | Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression |
| title_sort | somatic whole genome dynamics of precancer in barrett s esophagus reveals features associated with disease progression |
| url | https://doi.org/10.1038/s41467-022-29767-7 |
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