The contribution of hypothalamic macroglia to the regulation of energy homeostasis
The hypothalamus is critical for the regulation of energy homeostasis. Genetic and pharmacologic studies have identified a number of key hypothalamic neuronal circuits that integrate signals controlling food intake and energy expenditure. Recently studies have begun to emerge demonstrating a role fo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00212/full |
| _version_ | 1818518777231310848 |
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| author | Laura B Buckman Laura B Buckman Kate LJ Ellacott |
| author_facet | Laura B Buckman Laura B Buckman Kate LJ Ellacott |
| author_sort | Laura B Buckman |
| collection | DOAJ |
| description | The hypothalamus is critical for the regulation of energy homeostasis. Genetic and pharmacologic studies have identified a number of key hypothalamic neuronal circuits that integrate signals controlling food intake and energy expenditure. Recently studies have begun to emerge demonstrating a role for non-neuronal cell types in the regulation of energy homeostasis. In particular the potential importance of different glial cell types is increasingly being recognized. A number of studies have described changes in the activity of hypothalamic macroglia (principally astrocytes and tanycytes) in response to states of positive and negative energy balance, such as obesity and fasting. This article will review these studies and discuss how these findings are changing our understanding of the cellular mechanisms by which energy homeostasis is regulated. |
| first_indexed | 2024-12-11T01:14:55Z |
| format | Article |
| id | doaj.art-a39e1b78244945f0a7e45185be5c0243 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-11T01:14:55Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-a39e1b78244945f0a7e45185be5c02432022-12-22T01:25:56ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372014-10-01810.3389/fnsys.2014.00212104654The contribution of hypothalamic macroglia to the regulation of energy homeostasisLaura B Buckman0Laura B Buckman1Kate LJ Ellacott2Vanderbilt University Medical CenterUniversity of North Carolina at Chapel HillUniversity of Exeter Medical SchoolThe hypothalamus is critical for the regulation of energy homeostasis. Genetic and pharmacologic studies have identified a number of key hypothalamic neuronal circuits that integrate signals controlling food intake and energy expenditure. Recently studies have begun to emerge demonstrating a role for non-neuronal cell types in the regulation of energy homeostasis. In particular the potential importance of different glial cell types is increasingly being recognized. A number of studies have described changes in the activity of hypothalamic macroglia (principally astrocytes and tanycytes) in response to states of positive and negative energy balance, such as obesity and fasting. This article will review these studies and discuss how these findings are changing our understanding of the cellular mechanisms by which energy homeostasis is regulated.http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00212/fullFastingHypothalamusInflammationObesityastrocytehigh-fat diet |
| spellingShingle | Laura B Buckman Laura B Buckman Kate LJ Ellacott The contribution of hypothalamic macroglia to the regulation of energy homeostasis Frontiers in Systems Neuroscience Fasting Hypothalamus Inflammation Obesity astrocyte high-fat diet |
| title | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
| title_full | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
| title_fullStr | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
| title_full_unstemmed | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
| title_short | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
| title_sort | contribution of hypothalamic macroglia to the regulation of energy homeostasis |
| topic | Fasting Hypothalamus Inflammation Obesity astrocyte high-fat diet |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00212/full |
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