Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial
Osteopathic manipulative treatment (OMT) has been found to be effective in the context of premature infants. Nonetheless, no studies have investigated the immediate effects of OMT on heart rate variability (HRV). As altered HRV reflects poor or worsening newborn’s clinical conditions and neurodevelo...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Online Access: | https://www.mdpi.com/2227-9032/10/5/813 |
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| author | Andrea Manzotti Francesco Cerritelli Erica Lombardi Elena Monzani Luca Savioli Jorge E. Esteves Matteo Galli Simona La Rocca Pamela Biasi Marco Chiera Gianluca Lista |
| author_facet | Andrea Manzotti Francesco Cerritelli Erica Lombardi Elena Monzani Luca Savioli Jorge E. Esteves Matteo Galli Simona La Rocca Pamela Biasi Marco Chiera Gianluca Lista |
| author_sort | Andrea Manzotti |
| collection | DOAJ |
| description | Osteopathic manipulative treatment (OMT) has been found to be effective in the context of premature infants. Nonetheless, no studies have investigated the immediate effects of OMT on heart rate variability (HRV). As altered HRV reflects poor or worsening newborn’s clinical conditions and neurodevelopment, should OMT improve HRV fluctuations, it could become a relevant intervention for improving the care of preterm newborns. Therefore, this study aimed to evaluate whether OMT could affect HRV. The study was carried out at the Buzzi Hospital in Milan. From the neonatal intensive care unit, ninety-six preterm infants (41 males) were enrolled and were randomly assigned to one of two treatment groups: OMT or Static Touch. The infants were born at 33.5 weeks (±4.3) and had a mean birth weight of 2067 g (±929). The study had as primary outcome the change in the beat-to-beat variance in heart rate measured through root mean square of consecutive RR interval differences (RMSSD); other metrics were used as secondary and exploratory analyses. Despite the lack of statistically significant results regarding the primary outcomeand some study limitations, compared to static touch, OMT seemed to favor a parasympathetic modulation and improved HRV, which could reflect improvement in newborn’s clinical conditions and development. |
| first_indexed | 2024-03-10T03:48:32Z |
| format | Article |
| id | doaj.art-a39f52ffa1884c2dad27decb36bf9d8a |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T03:48:32Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-a39f52ffa1884c2dad27decb36bf9d8a2023-11-23T11:13:26ZengMDPI AGHealthcare2227-90322022-04-0110581310.3390/healthcare10050813Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical TrialAndrea Manzotti0Francesco Cerritelli1Erica Lombardi2Elena Monzani3Luca Savioli4Jorge E. Esteves5Matteo Galli6Simona La Rocca7Pamela Biasi8Marco Chiera9Gianluca Lista10RAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyRAISE Lab, Foundation COME Collaboration, 65121 Pescara, ItalyDivision of Neonatology, “V. Buzzi” Children’s Hospital, ASST-FBF-Sacco, 20157 Milan, ItalyOsteopathic manipulative treatment (OMT) has been found to be effective in the context of premature infants. Nonetheless, no studies have investigated the immediate effects of OMT on heart rate variability (HRV). As altered HRV reflects poor or worsening newborn’s clinical conditions and neurodevelopment, should OMT improve HRV fluctuations, it could become a relevant intervention for improving the care of preterm newborns. Therefore, this study aimed to evaluate whether OMT could affect HRV. The study was carried out at the Buzzi Hospital in Milan. From the neonatal intensive care unit, ninety-six preterm infants (41 males) were enrolled and were randomly assigned to one of two treatment groups: OMT or Static Touch. The infants were born at 33.5 weeks (±4.3) and had a mean birth weight of 2067 g (±929). The study had as primary outcome the change in the beat-to-beat variance in heart rate measured through root mean square of consecutive RR interval differences (RMSSD); other metrics were used as secondary and exploratory analyses. Despite the lack of statistically significant results regarding the primary outcomeand some study limitations, compared to static touch, OMT seemed to favor a parasympathetic modulation and improved HRV, which could reflect improvement in newborn’s clinical conditions and development.https://www.mdpi.com/2227-9032/10/5/813osteopathic manipulative treatmentpreterm infantstouchheart rate variabilityautonomic nervous systemC-tactile |
| spellingShingle | Andrea Manzotti Francesco Cerritelli Erica Lombardi Elena Monzani Luca Savioli Jorge E. Esteves Matteo Galli Simona La Rocca Pamela Biasi Marco Chiera Gianluca Lista Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial Healthcare osteopathic manipulative treatment preterm infants touch heart rate variability autonomic nervous system C-tactile |
| title | Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial |
| title_full | Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial |
| title_fullStr | Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial |
| title_full_unstemmed | Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial |
| title_short | Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial |
| title_sort | osteopathic manipulative treatment regulates autonomic markers in preterm infants a randomized clinical trial |
| topic | osteopathic manipulative treatment preterm infants touch heart rate variability autonomic nervous system C-tactile |
| url | https://www.mdpi.com/2227-9032/10/5/813 |
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