Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy

Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy

Muscle atrophy is debilitating and can be induced by several stressors. Unfortunately, there are no effective pharmacological treatment until now. MicroRNA (miR)-29b is an important target that we identified to be commonly involved in multiple types of muscle atrophy. Although sequence-specific inhi...

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Bibliographic Details
Main Authors: Qi Liu, Weilin Yuan, Yuwei Yan, Bing Jin, Mengke You, Tianqi Liu, Mingchun Gao, Jin Li, Priyanka Gokulnath, Gururaja Vulugundam, Guoping Li, Bin Xu, Junjie Xiao
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Non-coding RNAs
miR-29b
muscle atrophy
Ang II
Dex
TNF-α
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000239

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