Individual Correlates of Infectivity of Influenza A Virus Infections in Households.
BACKGROUND:Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. METHODS:In a detailed study of influenza virus transmis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4859516?pdf=render |
| _version_ | 1817975733938552832 |
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| author | Tim K Tsang Vicky J Fang Kwok-Hung Chan Dennis K M Ip Gabriel M Leung J S Malik Peiris Benjamin J Cowling Simon Cauchemez |
| author_facet | Tim K Tsang Vicky J Fang Kwok-Hung Chan Dennis K M Ip Gabriel M Leung J S Malik Peiris Benjamin J Cowling Simon Cauchemez |
| author_sort | Tim K Tsang |
| collection | DOAJ |
| description | BACKGROUND:Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. METHODS:In a detailed study of influenza virus transmission within households in 2008-12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity. RESULTS:We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group. CONCLUSIONS:Individual viral load measured by RT-PCR in the nose and throat was at most weakly correlated with individual infectivity in households. Other correlates of infectivity should be examined in future studies. |
| first_indexed | 2024-04-13T21:53:58Z |
| format | Article |
| id | doaj.art-a3a26a8c19734927aaee6deb5d2db61a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T21:53:58Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a3a26a8c19734927aaee6deb5d2db61a2022-12-22T02:28:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015441810.1371/journal.pone.0154418Individual Correlates of Infectivity of Influenza A Virus Infections in Households.Tim K TsangVicky J FangKwok-Hung ChanDennis K M IpGabriel M LeungJ S Malik PeirisBenjamin J CowlingSimon CauchemezBACKGROUND:Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. METHODS:In a detailed study of influenza virus transmission within households in 2008-12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity. RESULTS:We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group. CONCLUSIONS:Individual viral load measured by RT-PCR in the nose and throat was at most weakly correlated with individual infectivity in households. Other correlates of infectivity should be examined in future studies.http://europepmc.org/articles/PMC4859516?pdf=render |
| spellingShingle | Tim K Tsang Vicky J Fang Kwok-Hung Chan Dennis K M Ip Gabriel M Leung J S Malik Peiris Benjamin J Cowling Simon Cauchemez Individual Correlates of Infectivity of Influenza A Virus Infections in Households. PLoS ONE |
| title | Individual Correlates of Infectivity of Influenza A Virus Infections in Households. |
| title_full | Individual Correlates of Infectivity of Influenza A Virus Infections in Households. |
| title_fullStr | Individual Correlates of Infectivity of Influenza A Virus Infections in Households. |
| title_full_unstemmed | Individual Correlates of Infectivity of Influenza A Virus Infections in Households. |
| title_short | Individual Correlates of Infectivity of Influenza A Virus Infections in Households. |
| title_sort | individual correlates of infectivity of influenza a virus infections in households |
| url | http://europepmc.org/articles/PMC4859516?pdf=render |
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