Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors
One big threat from influenza A viruses (IAVs) is that novel viruses emerge from mutation alongside reassortment. Some of them have gained the capability to transmit into human from the avian reservoir. Understanding the molecular events and the involved factors in breaking the cross-species barrier...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.777885/full |
| _version_ | 1818836373262565376 |
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| author | Miaomiao Zhang Miaomiao Zhang Mingbin Liu Shimeng Bai Chen Zhao Zejun Li Jianqing Xu Xiaoyan Zhang |
| author_facet | Miaomiao Zhang Miaomiao Zhang Mingbin Liu Shimeng Bai Chen Zhao Zejun Li Jianqing Xu Xiaoyan Zhang |
| author_sort | Miaomiao Zhang |
| collection | DOAJ |
| description | One big threat from influenza A viruses (IAVs) is that novel viruses emerge from mutation alongside reassortment. Some of them have gained the capability to transmit into human from the avian reservoir. Understanding the molecular events and the involved factors in breaking the cross-species barrier holds important implication for the surveillance and prevention of potential influenza outbreaks. In this review, we summarize recent progresses, including several ground-breaking findings, in how the interaction between host and viral factors, exemplified by the PB2 subunit of the influenza virus RNA polymerase co-opting host ANP32 protein to facilitate transcription and replication of the viral genome, shapes the evolution of IAVs from host specificity to cross-species infection. |
| first_indexed | 2024-12-19T03:05:34Z |
| format | Article |
| id | doaj.art-a3a5825221cd42bd8cf83fac15fd736b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-19T03:05:34Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a3a5825221cd42bd8cf83fac15fd736b2022-12-21T20:38:08ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-11-011210.3389/fmicb.2021.777885777885Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host FactorsMiaomiao Zhang0Miaomiao Zhang1Mingbin Liu2Shimeng Bai3Chen Zhao4Zejun Li5Jianqing Xu6Xiaoyan Zhang7Scientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Veterinary Research Institute, Chinese Academic of Agricultural Sciences & Animal Influenza Virus Evolution and Pathogenesis Innovation Team of the Agricultural Science and Technology Innovation Team, Shanghai, ChinaScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, ChinaScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, ChinaScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Veterinary Research Institute, Chinese Academic of Agricultural Sciences & Animal Influenza Virus Evolution and Pathogenesis Innovation Team of the Agricultural Science and Technology Innovation Team, Shanghai, ChinaScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, ChinaScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, ChinaOne big threat from influenza A viruses (IAVs) is that novel viruses emerge from mutation alongside reassortment. Some of them have gained the capability to transmit into human from the avian reservoir. Understanding the molecular events and the involved factors in breaking the cross-species barrier holds important implication for the surveillance and prevention of potential influenza outbreaks. In this review, we summarize recent progresses, including several ground-breaking findings, in how the interaction between host and viral factors, exemplified by the PB2 subunit of the influenza virus RNA polymerase co-opting host ANP32 protein to facilitate transcription and replication of the viral genome, shapes the evolution of IAVs from host specificity to cross-species infection.https://www.frontiersin.org/articles/10.3389/fmicb.2021.777885/fullinfluenza A virushost specificitypathogenesishost factorsPB2 |
| spellingShingle | Miaomiao Zhang Miaomiao Zhang Mingbin Liu Shimeng Bai Chen Zhao Zejun Li Jianqing Xu Xiaoyan Zhang Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors Frontiers in Microbiology influenza A virus host specificity pathogenesis host factors PB2 |
| title | Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors |
| title_full | Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors |
| title_fullStr | Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors |
| title_full_unstemmed | Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors |
| title_short | Influenza A Virus–Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors |
| title_sort | influenza a virus host specificity an ongoing cross talk between viral and host factors |
| topic | influenza A virus host specificity pathogenesis host factors PB2 |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.777885/full |
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