A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin
Microglia-mediated neuroinflammation is closely related to depression. Many studies have shown that the NF-κB pathway was involved in the anti-neuroinflammatory effects of luteolin. However, more detailed molecular mechanisms should be further studied. In this study, our data indicated that luteolin...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003759 |
| _version_ | 1811187851088363520 |
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| author | Zhipeng Li Qingchen Wang Zhonghong Zhang Xiao Zhang Xintong Wu Li Li Yi Zhang Yihua Yu |
| author_facet | Zhipeng Li Qingchen Wang Zhonghong Zhang Xiao Zhang Xintong Wu Li Li Yi Zhang Yihua Yu |
| author_sort | Zhipeng Li |
| collection | DOAJ |
| description | Microglia-mediated neuroinflammation is closely related to depression. Many studies have shown that the NF-κB pathway was involved in the anti-neuroinflammatory effects of luteolin. However, more detailed molecular mechanisms should be further studied. In this study, our data indicated that luteolin inhibited neuroinflammation and alleviated depression-like behavior in a lipopolysaccharide (LPS)-induced mouse model. Further investigation revealed that luteolin increased the expression of A20 and Nrf2 and decreased the expression of TRAF6 while removing K63-linked polyubiquitin chains from TRAF6. Knockdown treatment using siRNA-A20 or Nrf2 reversed the effects of luteolin on neuroinflammation. This study explored the novel mechanism by which luteolin exerted anti-neuroinflammatory and antidepressant-like effects in a lipopolysaccharide-induced mouse model, which might be related to the upregulation of A20 and Nrf2. Notably, A20 exerted its function as a downstream factor of Nrf2. This study provides evidence for the potential application of luteolin in the prevention and treatment of neuroinflammation and depression. |
| first_indexed | 2024-04-11T14:10:32Z |
| format | Article |
| id | doaj.art-a3a60597f0804ef8aad762f207a68e64 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T14:10:32Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-a3a60597f0804ef8aad762f207a68e642022-12-22T04:19:45ZengElsevierJournal of Functional Foods1756-46462022-12-0199105305A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolinZhipeng Li0Qingchen Wang1Zhonghong Zhang2Xiao Zhang3Xintong Wu4Li Li5Yi Zhang6Yihua Yu7School of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, China; Corresponding authors.School of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, ChinaSchool of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, ChinaSchool of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, ChinaSchool of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, ChinaDepartment of Pharmacy, Zhejiang Hospital, Hangzhou 310013, Zhejiang, ChinaDepartment of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, ChinaDepartment of Critical Care Medicine, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China; Corresponding authors.Microglia-mediated neuroinflammation is closely related to depression. Many studies have shown that the NF-κB pathway was involved in the anti-neuroinflammatory effects of luteolin. However, more detailed molecular mechanisms should be further studied. In this study, our data indicated that luteolin inhibited neuroinflammation and alleviated depression-like behavior in a lipopolysaccharide (LPS)-induced mouse model. Further investigation revealed that luteolin increased the expression of A20 and Nrf2 and decreased the expression of TRAF6 while removing K63-linked polyubiquitin chains from TRAF6. Knockdown treatment using siRNA-A20 or Nrf2 reversed the effects of luteolin on neuroinflammation. This study explored the novel mechanism by which luteolin exerted anti-neuroinflammatory and antidepressant-like effects in a lipopolysaccharide-induced mouse model, which might be related to the upregulation of A20 and Nrf2. Notably, A20 exerted its function as a downstream factor of Nrf2. This study provides evidence for the potential application of luteolin in the prevention and treatment of neuroinflammation and depression.http://www.sciencedirect.com/science/article/pii/S1756464622003759NeuroinflammationDepressionLuteolinMicroglia |
| spellingShingle | Zhipeng Li Qingchen Wang Zhonghong Zhang Xiao Zhang Xintong Wu Li Li Yi Zhang Yihua Yu A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin Journal of Functional Foods Neuroinflammation Depression Luteolin Microglia |
| title | A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin |
| title_full | A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin |
| title_fullStr | A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin |
| title_full_unstemmed | A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin |
| title_short | A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin |
| title_sort | a20 as a downstream factor of nrf2 is involved in the anti neuroinflammatory and antidepressant like effects of luteolin |
| topic | Neuroinflammation Depression Luteolin Microglia |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622003759 |
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