Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models

Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models

Summary: Recent studies suggest that infection reprograms hematopoietic stem and progenitor cells (HSPCs) to enhance innate immune responses upon secondary infectious challenge, a process called “trained immunity.” However, the specificity and cell types responsible for this response remain poorly d...

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Bibliographic Details
Main Authors: Bailee N. Kain, Brandon T. Tran, Pamela N. Luna, Ruoqiong Cao, Duy T. Le, Marcus A. Florez, Laure Maneix, Jack D. Toups, Daniel E. Morales-Mantilla, Scott Koh, Hyojeong Han, Roman Jaksik, Yun Huang, Andre Catic, Chad A. Shaw, Katherine Y. King
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Cell biology
Immunology
Microbiology
Stem cells research
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223016735

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223016735

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