Anticholinergic medications even in therapeutic range can cause recurrence of psychosis
Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome (EPS). Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or induced delirium. Anticholinergic induced worsening of psychosis in patients with...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-06-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/33/4/e100235.full |
| _version_ | 1818777694305779712 |
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| author | Seshadri Sekhar Chatterjee Soumitra Das Barikar Chandrappa Malathesh |
| author_facet | Seshadri Sekhar Chatterjee Soumitra Das Barikar Chandrappa Malathesh |
| author_sort | Seshadri Sekhar Chatterjee |
| collection | DOAJ |
| description | Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome (EPS). Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or induced delirium. Anticholinergic induced worsening of psychosis in patients with normal cognition is extremely rare in literature. Here, we arepresenting a case of young female who was prescribed with multiple anticholinergics to reduce EPS, and each time had worsening of psychosis with intact cognition. We then discussed the possible neurobiological explanation with special reference to muscarinic hypothesis of schizophrenia. |
| first_indexed | 2024-12-18T11:32:54Z |
| format | Article |
| id | doaj.art-a3aa6ea4777348fa8d105bdc267550e8 |
| institution | Directory Open Access Journal |
| issn | 2517-729X |
| language | English |
| last_indexed | 2024-12-18T11:32:54Z |
| publishDate | 2020-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj.art-a3aa6ea4777348fa8d105bdc267550e82022-12-21T21:09:35ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2020-06-0133410.1136/gpsych-2020-100235Anticholinergic medications even in therapeutic range can cause recurrence of psychosisSeshadri Sekhar Chatterjee0Soumitra Das1Barikar Chandrappa Malathesh2Psychiatry, Diamond Harbour Medical College, Diamond Harbour, IndiaPsychiatry, NorthWestern Mental Health, Melbourne, Victoria, Australia1 Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome (EPS). Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or induced delirium. Anticholinergic induced worsening of psychosis in patients with normal cognition is extremely rare in literature. Here, we arepresenting a case of young female who was prescribed with multiple anticholinergics to reduce EPS, and each time had worsening of psychosis with intact cognition. We then discussed the possible neurobiological explanation with special reference to muscarinic hypothesis of schizophrenia.https://gpsych.bmj.com/content/33/4/e100235.full |
| spellingShingle | Seshadri Sekhar Chatterjee Soumitra Das Barikar Chandrappa Malathesh Anticholinergic medications even in therapeutic range can cause recurrence of psychosis General Psychiatry |
| title | Anticholinergic medications even in therapeutic range can cause recurrence of psychosis |
| title_full | Anticholinergic medications even in therapeutic range can cause recurrence of psychosis |
| title_fullStr | Anticholinergic medications even in therapeutic range can cause recurrence of psychosis |
| title_full_unstemmed | Anticholinergic medications even in therapeutic range can cause recurrence of psychosis |
| title_short | Anticholinergic medications even in therapeutic range can cause recurrence of psychosis |
| title_sort | anticholinergic medications even in therapeutic range can cause recurrence of psychosis |
| url | https://gpsych.bmj.com/content/33/4/e100235.full |
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