Cerebroprotein hydrolysate attenuates neurodegenerative changes in Alzheimer’s mice model via ferroptosis pathway

Cerebroprotein hydrolysate attenuates neurodegenerative changes in Alzheimer’s mice model via ferroptosis pathway

Introduction: Cerebroprotein hydrolysate has been proven to improve cognitive function in patients with Alzheimer’s disease (AD). We explored the safety and effectiveness of the clinical administration of oral cerebroprotein hydrolysate in AD, and possible mechanisms related to the neuronal ferropto...

Full description

Bibliographic Details
Main Authors:	Moxi Chen, Wei Song, Zhengju Chen, Xiaodong Shi, Xue Wang, Rongrong Li, Honglin Hao, Wei Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Series:	Frontiers in Pharmacology
Subjects:	Alzheimer’s disease ferroptosis oxidative stress cerebroprotein hydrolysate APP/PS1 mice
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1177503/full

Similar Items

Cerebroprotein Hydrolysate-I Inhibits Hippocampal Neuronal Apoptosis by Activating PI3K/Akt Signaling Pathway in Vascular Dementia Mice
by: Wu X, et al.
Published: (2021-07-01)

The use of cerebroprotein hydrolysate in dementia: A case series of 25 cases seen in a tertiary general hospital
by: Mosam Phirke, et al.
Published: (2014-01-01)

The Cerebroprotein Hydrolysate-I Plays a Neuroprotective Effect on Cerebral Ischemic Stroke by Inhibiting MEK/ERK1/2 Signaling Pathway in Rats
by: Ren Y, et al.
Published: (2021-07-01)

Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease
by: Xiaojie Wei, et al.
Published: (2018-09-01)

YXQN Reduces Alzheimer’s Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice
by: Xiaowan Wang, et al.
Published: (2017-05-01)

A Preclinical Model of Computerized Cognitive Training: Touchscreen Cognitive Testing Enhances Cognition and Hippocampal Cellular Plasticity in Wildtype and Alzheimer’s Disease Mice
by: Amy Shepherd, et al.
Published: (2021-12-01)

Xueshuantong Improves Functions of Lymphatic Ducts and Modulates Inflammatory Responses in Alzheimer’s Disease Mice
by: Rui Zheng, et al.
Published: (2021-09-01)

Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response
by: Nancy R. Stallings, et al.
Published: (2023-10-01)

Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer’s Disease
by: Oksana Fihurka, et al.
Published: (2023-01-01)

Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease
by: Jinghang Zhang, et al.
Published: (2020-11-01)

Examination of Longitudinal Alterations in Alzheimer’s Disease-Related Neurogenesis in an APP/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon
by: Titanilla Szögi, et al.
Published: (2022-09-01)

Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice
by: Shengxi Meng, et al.
Published: (2021-12-01)

Molecular Biology of Alzheimer’s Disease
by: M. Baki Yokeş, et al.
Published: (2005-04-01)

Yizhiqingxin Formula Alleviates Cognitive Deficits and Enhances Autophagy via mTOR Signaling Pathway Modulation in Early Onset Alzheimer’s Disease Mice
by: Yang Yang, et al.
Published: (2019-09-01)

Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer’s Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques
by: Dan Su, et al.
Published: (2021-04-01)

Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model
by: Xixia Chu, et al.
Published: (2022-09-01)

Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology
by: Yuqing Liu, et al.
Published: (2023-04-01)

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease
by: Cátia R. Lopes, et al.
Published: (2023-04-01)

Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice
by: Xue Li, et al.
Published: (2023-12-01)

Using mice to model Alzheimer’s dementia: an overview of the clinical disease and the preclinical behavioral changes in ten mouse models
by: Scott J Webster, et al.
Published: (2014-04-01)

Cerebroprotein hydrolysate allergy in patients with traumatic brain injury
by: Sobhana Devi Pydi, et al.
Published: (2021-09-01)

Intermittent hypoxia improves cognition and reduces anxiety‐related behavior in APP/PS1 mice
by: Sheng‐Xi Meng, et al.
Published: (2020-02-01)

Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer’s Disease Model
by: Eunju Kim, et al.
Published: (2021-07-01)

Digestibility, toxicity and metabolic effects of rapeseed and sunflower protein hydrolysates in mice
by: Donatella Canistro, et al.
Published: (2017-07-01)

Electroacupuncture Ameliorates Cognitive Impairment by Inhibiting the JNK Signaling Pathway in a Mouse Model of Alzheimer’s Disease
by: Yinshan Tang, et al.
Published: (2020-02-01)

Acacetin improves cognitive function of APP/PS1 Alzheimer’s disease model mice via the NLRP3 inflammasome signaling pathway
by: Bu Juan, et al.
Published: (2022-10-01)

CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer's disease.
by: Zehui Liu, et al.
Published: (2019-01-01)

Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice
by: Yu-Zhong Zhang, et al.
Published: (2010-02-01)

Isoforsythiaside confers neuroprotection against Alzheimer’s disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro
by: Chunyue Wang, et al.
Published: (2023-09-01)

Gastrodin as a multi-target protective compound reverses learning memory deficits and AD-like pathology in APP/PS1 transgenic mice
by: Yue-Qin Zeng, et al.
Published: (2021-02-01)

Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition
by: Tanja Blume, et al.
Published: (2022-03-01)

Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine
by: LIU Jiani, et al.
Published: (2022-06-01)

Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
by: Fanchang Wu, et al.
Published: (2023-07-01)

Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
by: Haiwang Zhang, et al.
Published: (2021-07-01)

N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy
by: Chun-mei Long, et al.
Published: (2021-12-01)

Fluoxetine Promotes Hippocampal Oligodendrocyte Maturation and Delays Learning and Memory Decline in APP/PS1 Mice
by: Feng-lei Chao, et al.
Published: (2021-01-01)

Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine
by: Louise Ørum Olesen, et al.
Published: (2017-08-01)

Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice
by: Qiang Su, et al.
Published: (2024-03-01)

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation
by: Kun Cao, et al.
Published: (2019-04-01)

AdipoRon induces AMPK activation and ameliorates Alzheimer's like pathologies and associated cognitive impairment in APP/PS1 mice
by: Mayuri Khandelwal, et al.
Published: (2022-11-01)