Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma

Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma

Alveolar macrophages are the first line of defense against intruding pathogens and play a critical role in cancer immunology. The Toll-like receptor (TLR) family mediates an important role in recognizing and mounting an immune response against intruding microbes. TLR-9 is a member of the intracellul...

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Bibliographic Details
Main Authors: Mohammed F. Aldawsari, Ahmed Alalaiwe, El-Sayed Khafagy, Ahmed Al Saqr, Saad M. Alshahrani, Bader B. Alsulays, Sultan Alshehri, Amr S. Abu Lila, Syed Mohd Danish Rizvi, Wael A. H. Hegazy
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
schizophyllan
CpG ODN 1826
inflammatory cytokines
Th1
lung cancer
M1 and M2
Online Access:https://www.mdpi.com/1422-0067/22/13/6833

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