Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions
<b>Background:</b> During esophagogastroduodenoscopy performed with colonoscopy, gastric and duodenal erythema, erosions, and ulcerations are often observed. This investigation was designed to review the prevalence of gastroduodenal lesions in patients who have undergone wireless capsule...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Gastrointestinal Disorders |
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| Online Access: | https://www.mdpi.com/2624-5647/6/1/24 |
| _version_ | 1797240910170292224 |
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| author | Anas Khouri Cesar G. Moreno Jack A. Di Palma |
| author_facet | Anas Khouri Cesar G. Moreno Jack A. Di Palma |
| author_sort | Anas Khouri |
| collection | DOAJ |
| description | <b>Background:</b> During esophagogastroduodenoscopy performed with colonoscopy, gastric and duodenal erythema, erosions, and ulcerations are often observed. This investigation was designed to review the prevalence of gastroduodenal lesions in patients who have undergone wireless capsule endoscopy using standard bowel cleansing preparations, but no endoscopy or sedation. <b>Methods:</b> A retrospective analysis was conducted on patients referred for capsule endoscopy. Records and capsule reports were reviewed for the patient demographics, preparation prescribed, procedural indications, and gastroduodenal findings. The preparations studied included polyethylene glycol lavage (PEG), PEG plus bisacodyl (PEG + bis), bisacodyl (bis), oral sulfate solution (OSS), and no prep. <b>Results:</b> Among the 1236 records, 498 (40.3%) were men and 738 (59.7%) were women. The mean age was 56 years +/− 18 years SD. The percentage of patients with lesions after any bowel preparation was 52.7% for gastric lesions and 23.6% for duodenal lesions. The percentage of patients with gastroduodenal lesions was 58.3% with prep, compared to 38.2% without prep. These findings were statistically significant, with an RR of 1.53 [1.19–1.94] (<i>p</i>-value = 0.00004). This difference was more pronounced in the OSS group RR of 1.65 [1.29–2.1] and bisacodyl group RR of 1.64 [1.25–2.15] compared to the PEG group RR of 0.95 [0.7–1.3]. <b>Conclusions:</b> This study showed that patients undergoing wireless capsule endoscopy who received bowel preparations had a significant increase in gastric and duodenal lesions. Of the preparations studied, OSS was associated with a greater number of gastroduodenal lesions, while PEG was the least associated with lesions, with an occurrence similar to the non-prep group. The clinical significance of these lesions remains undetermined. Endoscopists should be aware that preparations are associated with gastroduodenal lesions to avoid the misinterpretation and misdiagnosis of these lesions. |
| first_indexed | 2024-04-24T18:14:56Z |
| format | Article |
| id | doaj.art-a3ad27e8bcde444e934fc491d0fe602c |
| institution | Directory Open Access Journal |
| issn | 2624-5647 |
| language | English |
| last_indexed | 2024-04-24T18:14:56Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastrointestinal Disorders |
| spelling | doaj.art-a3ad27e8bcde444e934fc491d0fe602c2024-03-27T13:42:33ZengMDPI AGGastrointestinal Disorders2624-56472024-03-016135936710.3390/gidisord6010024Bowel Cleansing Preparations Are Associated with Gastroduodenal LesionsAnas Khouri0Cesar G. Moreno1Jack A. Di Palma2Division of Gastroenterology, Department of Internal Medicine, University of South Alabama Frederick P. Whiddon College of Medicine, Mobile, AL 36688, USADivision of Gastroenterology, Department of Internal Medicine, University of South Alabama Frederick P. Whiddon College of Medicine, Mobile, AL 36688, USADivision of Gastroenterology, Department of Internal Medicine, University of South Alabama Frederick P. Whiddon College of Medicine, Mobile, AL 36688, USA<b>Background:</b> During esophagogastroduodenoscopy performed with colonoscopy, gastric and duodenal erythema, erosions, and ulcerations are often observed. This investigation was designed to review the prevalence of gastroduodenal lesions in patients who have undergone wireless capsule endoscopy using standard bowel cleansing preparations, but no endoscopy or sedation. <b>Methods:</b> A retrospective analysis was conducted on patients referred for capsule endoscopy. Records and capsule reports were reviewed for the patient demographics, preparation prescribed, procedural indications, and gastroduodenal findings. The preparations studied included polyethylene glycol lavage (PEG), PEG plus bisacodyl (PEG + bis), bisacodyl (bis), oral sulfate solution (OSS), and no prep. <b>Results:</b> Among the 1236 records, 498 (40.3%) were men and 738 (59.7%) were women. The mean age was 56 years +/− 18 years SD. The percentage of patients with lesions after any bowel preparation was 52.7% for gastric lesions and 23.6% for duodenal lesions. The percentage of patients with gastroduodenal lesions was 58.3% with prep, compared to 38.2% without prep. These findings were statistically significant, with an RR of 1.53 [1.19–1.94] (<i>p</i>-value = 0.00004). This difference was more pronounced in the OSS group RR of 1.65 [1.29–2.1] and bisacodyl group RR of 1.64 [1.25–2.15] compared to the PEG group RR of 0.95 [0.7–1.3]. <b>Conclusions:</b> This study showed that patients undergoing wireless capsule endoscopy who received bowel preparations had a significant increase in gastric and duodenal lesions. Of the preparations studied, OSS was associated with a greater number of gastroduodenal lesions, while PEG was the least associated with lesions, with an occurrence similar to the non-prep group. The clinical significance of these lesions remains undetermined. Endoscopists should be aware that preparations are associated with gastroduodenal lesions to avoid the misinterpretation and misdiagnosis of these lesions.https://www.mdpi.com/2624-5647/6/1/24bowel preparationduodenal lesionsgastric lesionsoral sulfate solution (OSS)polyethylene glycol (PEG) |
| spellingShingle | Anas Khouri Cesar G. Moreno Jack A. Di Palma Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions Gastrointestinal Disorders bowel preparation duodenal lesions gastric lesions oral sulfate solution (OSS) polyethylene glycol (PEG) |
| title | Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions |
| title_full | Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions |
| title_fullStr | Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions |
| title_full_unstemmed | Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions |
| title_short | Bowel Cleansing Preparations Are Associated with Gastroduodenal Lesions |
| title_sort | bowel cleansing preparations are associated with gastroduodenal lesions |
| topic | bowel preparation duodenal lesions gastric lesions oral sulfate solution (OSS) polyethylene glycol (PEG) |
| url | https://www.mdpi.com/2624-5647/6/1/24 |
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