CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS
Abstract. This study demonstrates ability of carbon monoxide to trigger mitochondrial pathway of apoptosis induction of Jurcat cells. We have shown that proapoptotic action of carbon monoxide is coupled to permeabilization of cellular mitochondrial membranes. Imbalance in Bcl-2 family of regulatory...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/527 |
| _version_ | 1826534273627193344 |
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| author | E. G. Starikova L. A. Tashireva E. V. Beldiagina O. A. Vasilieva V. V. Novitsky N. V. Ryazantseva |
| author_facet | E. G. Starikova L. A. Tashireva E. V. Beldiagina O. A. Vasilieva V. V. Novitsky N. V. Ryazantseva |
| author_sort | E. G. Starikova |
| collection | DOAJ |
| description | Abstract. This study demonstrates ability of carbon monoxide to trigger mitochondrial pathway of apoptosis induction of Jurcat cells. We have shown that proapoptotic action of carbon monoxide is coupled to permeabilization of cellular mitochondrial membranes. Imbalance in Bcl-2 family of regulatory proteins may be considered among possible reasons of the membrane pore formation. We have shown downregulated cl-2 and Bcl-xl mRNA expression and decreased levels of antiapoptotic proteins, along wih decreased mRNA expression and increase of Bad proapototic protein level in Jurkat cells following incubation with 50 μm of CORM-2, a carbon monoxide donor. |
| first_indexed | 2024-03-08T05:50:54Z |
| format | Article |
| id | doaj.art-a3ada925b35a4c20860c40247081ddf3 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:20:24Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-a3ada925b35a4c20860c40247081ddf32025-03-11T17:59:03ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01144-535335810.15789/1563-0625-2012-4-5-353-358524CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLSE. G. Starikova0L. A. Tashireva1E. V. Beldiagina2O. A. Vasilieva3V. V. Novitsky4N. V. Ryazantseva5НОЦ молекулярной медицины ГБОУ ВПО «Сибирский государственный медицинский университет» Министерства здравоохранения и социального развития РФ, г. ТомскНОЦ молекулярной медицины ГБОУ ВПО «Сибирский государственный медицинский университет» Министерства здравоохранения и социального развития РФ, г. ТомскНОЦ молекулярной медицины ГБОУ ВПО «Сибирский государственный медицинский университет» Министерства здравоохранения и социального развития РФ, г. ТомскНОЦ молекулярной медицины ГБОУ ВПО «Сибирский государственный медицинский университет» Министерства здравоохранения и социального развития РФ, г. ТомскНОЦ молекулярной медицины ГБОУ ВПО «Сибирский государственный медицинский университет» Министерства здравоохранения и социального развития РФ, г. ТомскНОЦ молекулярной медицины ГБОУ ВПО «Сибирский государственный медицинский университет» Министерства здравоохранения и социального развития РФ, г. ТомскAbstract. This study demonstrates ability of carbon monoxide to trigger mitochondrial pathway of apoptosis induction of Jurcat cells. We have shown that proapoptotic action of carbon monoxide is coupled to permeabilization of cellular mitochondrial membranes. Imbalance in Bcl-2 family of regulatory proteins may be considered among possible reasons of the membrane pore formation. We have shown downregulated cl-2 and Bcl-xl mRNA expression and decreased levels of antiapoptotic proteins, along wih decreased mRNA expression and increase of Bad proapototic protein level in Jurkat cells following incubation with 50 μm of CORM-2, a carbon monoxide donor.https://www.mimmun.ru/mimmun/article/view/527carbon monoxideapoptosismitochondia |
| spellingShingle | E. G. Starikova L. A. Tashireva E. V. Beldiagina O. A. Vasilieva V. V. Novitsky N. V. Ryazantseva CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS Медицинская иммунология carbon monoxide apoptosis mitochondia |
| title | CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS |
| title_full | CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS |
| title_fullStr | CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS |
| title_full_unstemmed | CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS |
| title_short | CARBON MONOXIDE: ITS ROLE IN MITOCHONDRIAL PATHWAY OF APOPTOSIS INDUCTION IN JURKAT CANCER CELLS |
| title_sort | carbon monoxide its role in mitochondrial pathway of apoptosis induction in jurkat cancer cells |
| topic | carbon monoxide apoptosis mitochondia |
| url | https://www.mimmun.ru/mimmun/article/view/527 |
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