Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disorders
Disco Interacting Protein 2 Homolog A (DIP2A) is expressed throughout the body and abundantly expressed in the brain tissue. It is activated by Follistatin-like 1 (FSTL1). Activated DIP2A interacts with several pathways, such as AMPK/mTOR and AKT pathways, to contribute to many biological processes,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222301569X |
| _version_ | 1797630624087932928 |
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| author | Baoyuan Zhang Xuesong Zhang Moussa Omorou Kai Zhao Yang Ruan Haiyan Luan |
| author_facet | Baoyuan Zhang Xuesong Zhang Moussa Omorou Kai Zhao Yang Ruan Haiyan Luan |
| author_sort | Baoyuan Zhang |
| collection | DOAJ |
| description | Disco Interacting Protein 2 Homolog A (DIP2A) is expressed throughout the body and abundantly expressed in the brain tissue. It is activated by Follistatin-like 1 (FSTL1). Activated DIP2A interacts with several pathways, such as AMPK/mTOR and AKT pathways, to contribute to many biological processes, such as oxidative stress, transcriptional regulation, and apoptosis. Dysregulated DIP2A activation has been implicated in numerous processes in the brain. If the upstream pathways of DIP2A remain globally unexplored, many proteins, including cortactin, AMPK, and AKT, have been identified as its downstream targets in the literature. Recent studies have linked DIP2A to a variety of mechanisms in many types of brain disorders, suggesting that regulation of DIP2A could provide novel diagnostic and therapeutic approaches for brain disorders. In this review, we comprehensively summarized and discussed the current research on DIP2A in various brain disorders, such as stroke, autism spectrum disorders (ASD), Alzheimer’s disease (AD), dyslexia, and glioma. |
| first_indexed | 2024-03-11T11:10:48Z |
| format | Article |
| id | doaj.art-a3adb3f54ebd4235a5462d5721e8d57e |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T11:10:48Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-a3adb3f54ebd4235a5462d5721e8d57e2023-11-12T04:39:16ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01168115771Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disordersBaoyuan Zhang0Xuesong Zhang1Moussa Omorou2Kai Zhao3Yang Ruan4Haiyan Luan5Department of Physiology, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, China; Key laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, ChinaFirst Affiliated Hospital, Jiamusi University, Jiamusi, Heilongjiang, ChinaKey laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, China; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, ChinaDepartment of Physiology, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, China; Key laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, ChinaThe Central Hospital of Jiamusi City, Jiamusi, Heilongjiang, China; Corresponding authors.Department of Physiology, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, China; Key laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang, China; Corresponding authors.Disco Interacting Protein 2 Homolog A (DIP2A) is expressed throughout the body and abundantly expressed in the brain tissue. It is activated by Follistatin-like 1 (FSTL1). Activated DIP2A interacts with several pathways, such as AMPK/mTOR and AKT pathways, to contribute to many biological processes, such as oxidative stress, transcriptional regulation, and apoptosis. Dysregulated DIP2A activation has been implicated in numerous processes in the brain. If the upstream pathways of DIP2A remain globally unexplored, many proteins, including cortactin, AMPK, and AKT, have been identified as its downstream targets in the literature. Recent studies have linked DIP2A to a variety of mechanisms in many types of brain disorders, suggesting that regulation of DIP2A could provide novel diagnostic and therapeutic approaches for brain disorders. In this review, we comprehensively summarized and discussed the current research on DIP2A in various brain disorders, such as stroke, autism spectrum disorders (ASD), Alzheimer’s disease (AD), dyslexia, and glioma.http://www.sciencedirect.com/science/article/pii/S075333222301569XDIP2ABrain disordersBrainOxidative stressMitochondria |
| spellingShingle | Baoyuan Zhang Xuesong Zhang Moussa Omorou Kai Zhao Yang Ruan Haiyan Luan Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disorders Biomedicine & Pharmacotherapy DIP2A Brain disorders Brain Oxidative stress Mitochondria |
| title | Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disorders |
| title_full | Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disorders |
| title_fullStr | Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disorders |
| title_full_unstemmed | Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disorders |
| title_short | Disco interacting protein 2 homolog A (DIP2A): A key component in the regulation of brain disorders |
| title_sort | disco interacting protein 2 homolog a dip2a a key component in the regulation of brain disorders |
| topic | DIP2A Brain disorders Brain Oxidative stress Mitochondria |
| url | http://www.sciencedirect.com/science/article/pii/S075333222301569X |
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