Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification
Summary: Background: Pseudomyxoma peritonei (PMP) is a rare disease characterized by mucinous ascites and deposits on the peritoneal surfaces. The study aimed to assess PMP patients according to the Peritoneal Surface Oncology Group International (PSOGI) classification, as a part of standardization...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Asian Journal of Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958421000531 |
| _version_ | 1818573737400729600 |
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| author | Jong Lyul Lee Meejeong Kim Jihun Kim Chan Wook Kim Ye Jin Ha Seon-Young Kim Dong-Hyung Cho Jin Cheon Kim |
| author_facet | Jong Lyul Lee Meejeong Kim Jihun Kim Chan Wook Kim Ye Jin Ha Seon-Young Kim Dong-Hyung Cho Jin Cheon Kim |
| author_sort | Jong Lyul Lee |
| collection | DOAJ |
| description | Summary: Background: Pseudomyxoma peritonei (PMP) is a rare disease characterized by mucinous ascites and deposits on the peritoneal surfaces. The study aimed to assess PMP patients according to the Peritoneal Surface Oncology Group International (PSOGI) classification, as a part of standardization of this rare disease. Methods: This retrospective study analyzed PMP patients who underwent surgery between January 2007 and December 2017. All histologic slides were re-evaluated and the clinical data were collected. According to the PSOGI, PMP was retrospectively classified into three categories: low-grade (LG-PMP), high-grade (HG-PMP), and signet-ring cells (SRC-PMP). The extent of peritoneal involvement was quantified by the peritoneal cancer index (PCI). The completeness of cytoreduction (CCR) was dichotomized as complete or incomplete. Results: Fifty-seven patients were included in this study, consisted of 39 patients with LG-PMP (74.0%), 14 with HG-PMP (20.8%), and 4 with SRC-PMP (5.2%). There was no operative mortality and major complications occurred in 24 patients (31.2%). The 5-year overall survival was 56.2% ± 8.1% for LG-PMP, 37.5% ± 12.1% for HG-PMP, and 25.0% ± 21.7% for SRC-PMP. Concerning CCR, the 5-year overall (complete: 59.5% ± 8.4% vs. incomplete: 12.7% ± 8.1%, p = 0.001) and disease-free survival (complete: 38.6% ± 8.9% vs. incomplete: 7.7% ± 6.8%, p = 0.001) were significantly different. In a multivariable analysis, PSOGI classification and CCR independently correlated with survival (p = 0.011 and 0.018, respectively). Conclusions: The PSOGI classification provides prognostic stratification, hopefully requiring further validation including every single case of PMP established as a standard criteria. |
| first_indexed | 2024-12-15T00:16:54Z |
| format | Article |
| id | doaj.art-a3b1376b1d9d47259a0c5481a7e8f4b6 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-15T00:16:54Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-a3b1376b1d9d47259a0c5481a7e8f4b62022-12-21T22:42:26ZengElsevierAsian Journal of Surgery1015-95842021-06-01446848853Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classificationJong Lyul Lee0Meejeong Kim1Jihun Kim2Chan Wook Kim3Ye Jin Ha4Seon-Young Kim5Dong-Hyung Cho6Jin Cheon Kim7Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea; Institute of Innovative Cancer Research, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South KoreaDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South KoreaDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South KoreaDepartment of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea; Institute of Innovative Cancer Research, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South KoreaInstitute of Innovative Cancer Research, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South KoreaMedical Genomics Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon, South KoreaSchool of Life Science, Kyungpook National University, Daegu, South KoreaDepartment of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea; Institute of Innovative Cancer Research, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea; Corresponding author. Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.Summary: Background: Pseudomyxoma peritonei (PMP) is a rare disease characterized by mucinous ascites and deposits on the peritoneal surfaces. The study aimed to assess PMP patients according to the Peritoneal Surface Oncology Group International (PSOGI) classification, as a part of standardization of this rare disease. Methods: This retrospective study analyzed PMP patients who underwent surgery between January 2007 and December 2017. All histologic slides were re-evaluated and the clinical data were collected. According to the PSOGI, PMP was retrospectively classified into three categories: low-grade (LG-PMP), high-grade (HG-PMP), and signet-ring cells (SRC-PMP). The extent of peritoneal involvement was quantified by the peritoneal cancer index (PCI). The completeness of cytoreduction (CCR) was dichotomized as complete or incomplete. Results: Fifty-seven patients were included in this study, consisted of 39 patients with LG-PMP (74.0%), 14 with HG-PMP (20.8%), and 4 with SRC-PMP (5.2%). There was no operative mortality and major complications occurred in 24 patients (31.2%). The 5-year overall survival was 56.2% ± 8.1% for LG-PMP, 37.5% ± 12.1% for HG-PMP, and 25.0% ± 21.7% for SRC-PMP. Concerning CCR, the 5-year overall (complete: 59.5% ± 8.4% vs. incomplete: 12.7% ± 8.1%, p = 0.001) and disease-free survival (complete: 38.6% ± 8.9% vs. incomplete: 7.7% ± 6.8%, p = 0.001) were significantly different. In a multivariable analysis, PSOGI classification and CCR independently correlated with survival (p = 0.011 and 0.018, respectively). Conclusions: The PSOGI classification provides prognostic stratification, hopefully requiring further validation including every single case of PMP established as a standard criteria.http://www.sciencedirect.com/science/article/pii/S1015958421000531Pseudomyxoma peritoneiSurvivalValidationClassificationGradeOutcome |
| spellingShingle | Jong Lyul Lee Meejeong Kim Jihun Kim Chan Wook Kim Ye Jin Ha Seon-Young Kim Dong-Hyung Cho Jin Cheon Kim Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification Asian Journal of Surgery Pseudomyxoma peritonei Survival Validation Classification Grade Outcome |
| title | Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification |
| title_full | Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification |
| title_fullStr | Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification |
| title_full_unstemmed | Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification |
| title_short | Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification |
| title_sort | evaluation of the significance of pseudomyxoma peritonei patients based on the peritoneal surface oncology group international psogi classification |
| topic | Pseudomyxoma peritonei Survival Validation Classification Grade Outcome |
| url | http://www.sciencedirect.com/science/article/pii/S1015958421000531 |
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