Specificity and plasticity of thalamocortical connections in Sema6A mutant mice.
The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate innervation. We show here that Sema6A mutants provide a unique model to te...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-04-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2672616 |
| _version_ | 1819094997455077376 |
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| author | Graham E Little Guillermina López-Bendito Annette E Rünker Noelia García Maria C Piñon Alain Chédotal Zoltán Molnár Kevin J Mitchell |
| author_facet | Graham E Little Guillermina López-Bendito Annette E Rünker Noelia García Maria C Piñon Alain Chédotal Zoltán Molnár Kevin J Mitchell |
| author_sort | Graham E Little |
| collection | DOAJ |
| description | The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate innervation. We show here that Sema6A mutants provide a unique model to test current ideas on the interactions between subcortical and cortical guidance mechanisms and cortical regionalization. In these mutants, axons from the dorsal lateral geniculate nucleus (dLGN) are misrouted in the ventral telencephalon. This leads to invasion of presumptive visual cortex by somatosensory thalamic axons at embryonic stages. Remarkably, the misrouted dLGN axons are able to find their way to the visual cortex via alternate routes at postnatal stages and reestablish a normal pattern of thalamocortical connectivity. These findings emphasize the importance and specificity of cortical cues in establishing thalamocortical connectivity and the spectacular capacity of the early postnatal cortex for remapping initial sensory representations. |
| first_indexed | 2024-12-21T23:36:18Z |
| format | Article |
| id | doaj.art-a3b165368abb4bcc887798198d4144c9 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-21T23:36:18Z |
| publishDate | 2009-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-a3b165368abb4bcc887798198d4144c92022-12-21T18:46:20ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852009-04-0174e9810.1371/journal.pbio.1000098Specificity and plasticity of thalamocortical connections in Sema6A mutant mice.Graham E LittleGuillermina López-BenditoAnnette E RünkerNoelia GarcíaMaria C PiñonAlain ChédotalZoltán MolnárKevin J MitchellThe establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate innervation. We show here that Sema6A mutants provide a unique model to test current ideas on the interactions between subcortical and cortical guidance mechanisms and cortical regionalization. In these mutants, axons from the dorsal lateral geniculate nucleus (dLGN) are misrouted in the ventral telencephalon. This leads to invasion of presumptive visual cortex by somatosensory thalamic axons at embryonic stages. Remarkably, the misrouted dLGN axons are able to find their way to the visual cortex via alternate routes at postnatal stages and reestablish a normal pattern of thalamocortical connectivity. These findings emphasize the importance and specificity of cortical cues in establishing thalamocortical connectivity and the spectacular capacity of the early postnatal cortex for remapping initial sensory representations.http://europepmc.org/articles/PMC2672616 |
| spellingShingle | Graham E Little Guillermina López-Bendito Annette E Rünker Noelia García Maria C Piñon Alain Chédotal Zoltán Molnár Kevin J Mitchell Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. PLoS Biology |
| title | Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. |
| title_full | Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. |
| title_fullStr | Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. |
| title_full_unstemmed | Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. |
| title_short | Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. |
| title_sort | specificity and plasticity of thalamocortical connections in sema6a mutant mice |
| url | http://europepmc.org/articles/PMC2672616 |
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