Identifying the Structural Components Responsible for the Antiproliferative Properties of Hydroxychavicol
Betel leaves are widely used as herbal medicine in Asia due to their antimicrobial properties. These properties have been attributed to the phenolic compound eugenol and its derivative, hydroxychavicol. Hydroxychavicol has also been shown to inhibit cancer cell proliferation. The main objective of t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Compounds |
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| Online Access: | https://www.mdpi.com/2673-6918/3/4/39 |
| _version_ | 1827575209889103872 |
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| author | Joshua Jackson Gerome M. Romero Diana Hawkins Richard G. Cornwall Georgi L. Lukov |
| author_facet | Joshua Jackson Gerome M. Romero Diana Hawkins Richard G. Cornwall Georgi L. Lukov |
| author_sort | Joshua Jackson |
| collection | DOAJ |
| description | Betel leaves are widely used as herbal medicine in Asia due to their antimicrobial properties. These properties have been attributed to the phenolic compound eugenol and its derivative, hydroxychavicol. Hydroxychavicol has also been shown to inhibit cancer cell proliferation. The main objective of this study was to investigate which structural components of hydroxychavicol are responsible for the antiproliferative property of this compound. Jurkat-E6 cells (JE6) were treated with increasing concentrations (5, 15, and 45 µM) of hydroxychavicol and structural variants of it for 48 h. The results of this study demonstrate that the catechol structure in hydroxychavicol is the structural component that exhibits the highest antiproliferative effect. More specifically, the data show that the six-carbon ring must be aromatic with the two hydroxyl groups attached in an ortho position. Furthermore, this study establishes that the oxygen in the hydroxyl groups has a vital role in the antiproliferative properties of catechol and hydroxychavicol. |
| first_indexed | 2024-03-08T20:52:58Z |
| format | Article |
| id | doaj.art-a3b2a03add064731aebdb24bcd8a9b8b |
| institution | Directory Open Access Journal |
| issn | 2673-6918 |
| language | English |
| last_indexed | 2024-03-08T20:52:58Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Compounds |
| spelling | doaj.art-a3b2a03add064731aebdb24bcd8a9b8b2023-12-22T14:01:14ZengMDPI AGCompounds2673-69182023-10-013455256010.3390/compounds3040039Identifying the Structural Components Responsible for the Antiproliferative Properties of HydroxychavicolJoshua Jackson0Gerome M. Romero1Diana Hawkins2Richard G. Cornwall3Georgi L. Lukov4Faculty of Science, Brigham Young University–Hawaii, Laie, HI 96762, USAFaculty of Science, Brigham Young University–Hawaii, Laie, HI 96762, USAFaculty of Science, Brigham Young University–Hawaii, Laie, HI 96762, USAFaculty of Science, Brigham Young University–Hawaii, Laie, HI 96762, USAFaculty of Science, Brigham Young University–Hawaii, Laie, HI 96762, USABetel leaves are widely used as herbal medicine in Asia due to their antimicrobial properties. These properties have been attributed to the phenolic compound eugenol and its derivative, hydroxychavicol. Hydroxychavicol has also been shown to inhibit cancer cell proliferation. The main objective of this study was to investigate which structural components of hydroxychavicol are responsible for the antiproliferative property of this compound. Jurkat-E6 cells (JE6) were treated with increasing concentrations (5, 15, and 45 µM) of hydroxychavicol and structural variants of it for 48 h. The results of this study demonstrate that the catechol structure in hydroxychavicol is the structural component that exhibits the highest antiproliferative effect. More specifically, the data show that the six-carbon ring must be aromatic with the two hydroxyl groups attached in an ortho position. Furthermore, this study establishes that the oxygen in the hydroxyl groups has a vital role in the antiproliferative properties of catechol and hydroxychavicol.https://www.mdpi.com/2673-6918/3/4/39hydroxychavicoleugenolcatecholcancerchemotherapyproliferation |
| spellingShingle | Joshua Jackson Gerome M. Romero Diana Hawkins Richard G. Cornwall Georgi L. Lukov Identifying the Structural Components Responsible for the Antiproliferative Properties of Hydroxychavicol Compounds hydroxychavicol eugenol catechol cancer chemotherapy proliferation |
| title | Identifying the Structural Components Responsible for the Antiproliferative Properties of Hydroxychavicol |
| title_full | Identifying the Structural Components Responsible for the Antiproliferative Properties of Hydroxychavicol |
| title_fullStr | Identifying the Structural Components Responsible for the Antiproliferative Properties of Hydroxychavicol |
| title_full_unstemmed | Identifying the Structural Components Responsible for the Antiproliferative Properties of Hydroxychavicol |
| title_short | Identifying the Structural Components Responsible for the Antiproliferative Properties of Hydroxychavicol |
| title_sort | identifying the structural components responsible for the antiproliferative properties of hydroxychavicol |
| topic | hydroxychavicol eugenol catechol cancer chemotherapy proliferation |
| url | https://www.mdpi.com/2673-6918/3/4/39 |
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