Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome
Metabolic disorders in pregnancy, particularly gestational diabetes mellitus (GDM), are associated with an increased risk for adverse pregnancy outcome and long-term cardiometabolic health of mother and child. This study analyzed changes of serum cholesterol synthesis and absorption markers during t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/10/959 |
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| author | Aleksandra Zeljković Daniela Ardalić Jelena Vekić Tamara Antonić Sandra Vladimirov Manfredi Rizzo Tamara Gojković Jasmina Ivanišević Marija Mihajlović Sanja Vujčić Petar Cabunac Vesna Spasojević-Kalimanovska Željko Miković Aleksandra Stefanović |
| author_facet | Aleksandra Zeljković Daniela Ardalić Jelena Vekić Tamara Antonić Sandra Vladimirov Manfredi Rizzo Tamara Gojković Jasmina Ivanišević Marija Mihajlović Sanja Vujčić Petar Cabunac Vesna Spasojević-Kalimanovska Željko Miković Aleksandra Stefanović |
| author_sort | Aleksandra Zeljković |
| collection | DOAJ |
| description | Metabolic disorders in pregnancy, particularly gestational diabetes mellitus (GDM), are associated with an increased risk for adverse pregnancy outcome and long-term cardiometabolic health of mother and child. This study analyzed changes of serum cholesterol synthesis and absorption markers during the course of high-risk pregnancies, with respect to the development of GDM. Possible associations of maternal lipid biomarkers with neonatal characteristics were also investigated. The study included 63 women with high risk for development of pregnancy complications. Size and proportions of small low-density (LDL) and high-density lipoprotein (HDL) particles were assessed across trimesters (T1–T3), as well as concentrations of cholesterol synthesis (lathosterol, desmosterol) and absorption markers (campesterol, β-sitosterol). During the study, 15 women developed GDM, while 48 had no complications (non-GDM). As compared to the non-GDM group, women with GDM had significantly higher triglycerides in each trimester, while having a lower HDL-C level in T3. In addition, they had significantly lower levels of β-sitosterol in T3 (<i>p</i> < 0.05). Cholesterol synthesis markers increased across trimesters in both groups. A decrease in serum β-sitosterol levels during the course of pregnancies affected by GDM was observed. The prevalence of small-sized HDL decreased in non-GDM, while in the GDM group remained unchanged across trimesters. Newborn’s size in the non-GDM group was significantly higher (<i>p</i> < 0.01) and inversely associated with proportions of both small, dense LDL and HDL particles (<i>p</i> < 0.05) in maternal plasma in T1. In conclusion, high-risk pregnancies affected by GDM are characterized by altered cholesterol absorption and HDL maturation. Advanced lipid testing may indicate disturbed lipid homeostasis in GDM. |
| first_indexed | 2024-03-09T19:49:28Z |
| format | Article |
| id | doaj.art-a3b44ab895534b4ab8be351c3fff310e |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T19:49:28Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-a3b44ab895534b4ab8be351c3fff310e2023-11-24T01:15:54ZengMDPI AGMetabolites2218-19892022-10-01121095910.3390/metabo12100959Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal OutcomeAleksandra Zeljković0Daniela Ardalić1Jelena Vekić2Tamara Antonić3Sandra Vladimirov4Manfredi Rizzo5Tamara Gojković6Jasmina Ivanišević7Marija Mihajlović8Sanja Vujčić9Petar Cabunac10Vesna Spasojević-Kalimanovska11Željko Miković12Aleksandra Stefanović13Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaGynecology and Obstetrics Clinic Narodni Front, 11000 Belgrade, SerbiaDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, ItalyDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaGynecology and Obstetrics Clinic Narodni Front, 11000 Belgrade, SerbiaDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaGynecology and Obstetrics Clinic Narodni Front, 11000 Belgrade, SerbiaDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, SerbiaMetabolic disorders in pregnancy, particularly gestational diabetes mellitus (GDM), are associated with an increased risk for adverse pregnancy outcome and long-term cardiometabolic health of mother and child. This study analyzed changes of serum cholesterol synthesis and absorption markers during the course of high-risk pregnancies, with respect to the development of GDM. Possible associations of maternal lipid biomarkers with neonatal characteristics were also investigated. The study included 63 women with high risk for development of pregnancy complications. Size and proportions of small low-density (LDL) and high-density lipoprotein (HDL) particles were assessed across trimesters (T1–T3), as well as concentrations of cholesterol synthesis (lathosterol, desmosterol) and absorption markers (campesterol, β-sitosterol). During the study, 15 women developed GDM, while 48 had no complications (non-GDM). As compared to the non-GDM group, women with GDM had significantly higher triglycerides in each trimester, while having a lower HDL-C level in T3. In addition, they had significantly lower levels of β-sitosterol in T3 (<i>p</i> < 0.05). Cholesterol synthesis markers increased across trimesters in both groups. A decrease in serum β-sitosterol levels during the course of pregnancies affected by GDM was observed. The prevalence of small-sized HDL decreased in non-GDM, while in the GDM group remained unchanged across trimesters. Newborn’s size in the non-GDM group was significantly higher (<i>p</i> < 0.01) and inversely associated with proportions of both small, dense LDL and HDL particles (<i>p</i> < 0.05) in maternal plasma in T1. In conclusion, high-risk pregnancies affected by GDM are characterized by altered cholesterol absorption and HDL maturation. Advanced lipid testing may indicate disturbed lipid homeostasis in GDM.https://www.mdpi.com/2218-1989/12/10/959high-risk pregnancygestational diabetescholesterol synthesis and absorptionLDL and HDL particlesneonatal outcome |
| spellingShingle | Aleksandra Zeljković Daniela Ardalić Jelena Vekić Tamara Antonić Sandra Vladimirov Manfredi Rizzo Tamara Gojković Jasmina Ivanišević Marija Mihajlović Sanja Vujčić Petar Cabunac Vesna Spasojević-Kalimanovska Željko Miković Aleksandra Stefanović Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome Metabolites high-risk pregnancy gestational diabetes cholesterol synthesis and absorption LDL and HDL particles neonatal outcome |
| title | Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome |
| title_full | Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome |
| title_fullStr | Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome |
| title_full_unstemmed | Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome |
| title_short | Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome |
| title_sort | effects of gestational diabetes mellitus on cholesterol metabolism in women with high risk pregnancies possible implications for neonatal outcome |
| topic | high-risk pregnancy gestational diabetes cholesterol synthesis and absorption LDL and HDL particles neonatal outcome |
| url | https://www.mdpi.com/2218-1989/12/10/959 |
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