Protective effects of melatonin in cisplatin-induced cardiac toxicity: possible role of BDNF-TNF-α signaling pathway

Protective effects of melatonin in cisplatin-induced cardiac toxicity: possible role of BDNF-TNF-α signaling pathway

ABSTRACT Purpose: The present study explored the role of melatonin in cisplatin-induced cardiac injury along with the possible role of brain-derived neurotrophic factor (BDNF) in melatonin-mediated effects. Methods: Wistar rats were administered cisplatin (10 mg/kg), and cardiac injury was assesse...

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Bibliographic Details
Main Authors: Xiaoqing Zhuo, Honglei Jiang
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2022-05-01
Series:Acta Cirúrgica Brasileira
Subjects:
Melatonin
Cisplatin
Glutathione
Brain-Derived Neurotrophic Factor
Rats
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000200207&lng=en&tlng=en

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