Evaluation Of Heat Shock Protein-27 Levels as A Predictor of Diabetic Nephropathy in Early Diabetics
Objective: The current study objective is to find out the levels of heat shock protein-27 in diabetes patients with and without diabetic nephropathy, and to appraise the functional role of HSP-27 as an early diagnostic biomarker in progressive diabetic nephropathy. Study Design: Case control stu...
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| Format: | Article |
| Language: | English |
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KARACHI MEDICAL AND DENTAL COLLEGE
2021-12-01
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| Series: | Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College |
| Online Access: | https://www.annals-ashkmdc.org/index.php/ashkmdc/article/view/484 |
| _version_ | 1797364242614059008 |
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| author | Muhammad Irfan Shabir Ahmed Adil Ramzan Nosheen Wasee Nuvair Zia Nargis Anjum |
| author_facet | Muhammad Irfan Shabir Ahmed Adil Ramzan Nosheen Wasee Nuvair Zia Nargis Anjum |
| author_sort | Muhammad Irfan |
| collection | DOAJ |
| description |
Objective: The current study objective is to find out the levels of heat shock protein-27 in diabetes patients with and without diabetic nephropathy, and to appraise the functional role of HSP-27 as an early diagnostic biomarker in progressive diabetic nephropathy.
Study Design: Case control study.
Place and Duration of Study: The current study was conducted in physiology department, Basic Medical Science Institute (BMSI), Jinnah Post-Graduate Medical Center (JPMC), Karachi from March 2019 to September 2020.
Methodology: A total 105 participants between 30-50 years of age were separated into three groups: Group A (n=35) diabetic-patients with history of diabetes < 5 years without any sign of DN; Group B (n=35) diabetic patients with history of diabetes >5 years duration of diabetes and microalbumin levels < 30 mg/dl in urine and Group C (n=35) healthy individuals. All this study participants were gone through detailed history, anthropometric measurement, BMI, serum blood sugar, serum urea, serum creatinine, BUN, urinary albumin, and serum HSP-27 were estimated.
Results: Elevated levels of HSP-27 were seen in group-A patients as compared to group-C (p<0.001). Elevated levels of HSP-27 were presented in group-B as compared with group-C (p<0.001) which signify early renal parenchyma injury. Strong association had been seen for HSP-27 with creatinine (r=0.69; p < 0.001), and HbA1c (r =0.72; p <0.001) and urea (r = 0.72; p <0.001) in all these participants. While statistical highly significant and strong positive association were reported for HSP-27 with microalbumin (r = 0.86; p< 0.001) in all participants.
Conclusion: Elevated levels of HSP-27 with progression of renal injury with or without declining of renal function is seen in current study. These findings perhaps suggest and recognizing HSP-27 as key diagnostic marker for diabetic nephropathy in early diabetics.
KEYWORDS: Diabetes Mellitus, Diabetic Nephropathy, HSP-27.
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| first_indexed | 2024-03-08T16:32:29Z |
| format | Article |
| id | doaj.art-a3b521d2069540a187824fe2b8a98e48 |
| institution | Directory Open Access Journal |
| issn | 1563-3241 |
| language | English |
| last_indexed | 2024-03-08T16:32:29Z |
| publishDate | 2021-12-01 |
| publisher | KARACHI MEDICAL AND DENTAL COLLEGE |
| record_format | Article |
| series | Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College |
| spelling | doaj.art-a3b521d2069540a187824fe2b8a98e482024-01-06T06:10:07ZengKARACHI MEDICAL AND DENTAL COLLEGEAnnals of Abbasi Shaheed Hospital and Karachi Medical & Dental College1563-32412021-12-0126310.58397/ashkmdc.v26i3.484350Evaluation Of Heat Shock Protein-27 Levels as A Predictor of Diabetic Nephropathy in Early DiabeticsMuhammad Irfan0Shabir Ahmed1Adil RamzanNosheen WaseeNuvair ZiaNargis AnjumBMSI, JPMCBMSI. jPMC Karachi Objective: The current study objective is to find out the levels of heat shock protein-27 in diabetes patients with and without diabetic nephropathy, and to appraise the functional role of HSP-27 as an early diagnostic biomarker in progressive diabetic nephropathy. Study Design: Case control study. Place and Duration of Study: The current study was conducted in physiology department, Basic Medical Science Institute (BMSI), Jinnah Post-Graduate Medical Center (JPMC), Karachi from March 2019 to September 2020. Methodology: A total 105 participants between 30-50 years of age were separated into three groups: Group A (n=35) diabetic-patients with history of diabetes < 5 years without any sign of DN; Group B (n=35) diabetic patients with history of diabetes >5 years duration of diabetes and microalbumin levels < 30 mg/dl in urine and Group C (n=35) healthy individuals. All this study participants were gone through detailed history, anthropometric measurement, BMI, serum blood sugar, serum urea, serum creatinine, BUN, urinary albumin, and serum HSP-27 were estimated. Results: Elevated levels of HSP-27 were seen in group-A patients as compared to group-C (p<0.001). Elevated levels of HSP-27 were presented in group-B as compared with group-C (p<0.001) which signify early renal parenchyma injury. Strong association had been seen for HSP-27 with creatinine (r=0.69; p < 0.001), and HbA1c (r =0.72; p <0.001) and urea (r = 0.72; p <0.001) in all these participants. While statistical highly significant and strong positive association were reported for HSP-27 with microalbumin (r = 0.86; p< 0.001) in all participants. Conclusion: Elevated levels of HSP-27 with progression of renal injury with or without declining of renal function is seen in current study. These findings perhaps suggest and recognizing HSP-27 as key diagnostic marker for diabetic nephropathy in early diabetics. KEYWORDS: Diabetes Mellitus, Diabetic Nephropathy, HSP-27. https://www.annals-ashkmdc.org/index.php/ashkmdc/article/view/484 |
| spellingShingle | Muhammad Irfan Shabir Ahmed Adil Ramzan Nosheen Wasee Nuvair Zia Nargis Anjum Evaluation Of Heat Shock Protein-27 Levels as A Predictor of Diabetic Nephropathy in Early Diabetics Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College |
| title | Evaluation Of Heat Shock Protein-27 Levels as A Predictor of Diabetic Nephropathy in Early Diabetics |
| title_full | Evaluation Of Heat Shock Protein-27 Levels as A Predictor of Diabetic Nephropathy in Early Diabetics |
| title_fullStr | Evaluation Of Heat Shock Protein-27 Levels as A Predictor of Diabetic Nephropathy in Early Diabetics |
| title_full_unstemmed | Evaluation Of Heat Shock Protein-27 Levels as A Predictor of Diabetic Nephropathy in Early Diabetics |
| title_short | Evaluation Of Heat Shock Protein-27 Levels as A Predictor of Diabetic Nephropathy in Early Diabetics |
| title_sort | evaluation of heat shock protein 27 levels as a predictor of diabetic nephropathy in early diabetics |
| url | https://www.annals-ashkmdc.org/index.php/ashkmdc/article/view/484 |
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