Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice

Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice

Positional cloning of ENU-induced mutations has traditionally relied on analysis of polymorphic variation between two strains. In contrast, the application of whole-genome sequencing (WGS) has enabled gene discovery in mutant lines maintained on an inbred genetic background. This approach utilizes g...

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Bibliographic Details
Main Authors: Krista A. Geister, Andrew E. Timms, David R. Beier
Format: Article
Language:English
Published: Oxford University Press 2018-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Mus musculus
Colgalt1
Plod3
Kif20b
Tgds
Fbn2
Mutant screen report
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300292

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