Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone
In this research, a novel method is reported for the surface grafting of n-vinylcaprolactam as a thermosensitive agent and 3-allyloxy-1,2-propandiol with an affinity toward ceftriaxone onto modified magnetic nanoparticles by 3-mercaptopropyltrimethoxysilane. The grafted nanoparticles were characteri...
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| Format: | Article |
| Language: | English |
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Iranian Society of Nanomedicine
2019-04-01
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| Series: | Nanomedicine Research Journal |
| Subjects: | |
| Online Access: | http://www.nanomedicine-rj.com/article_35944_f9378b44b7a14e57f0350fcf9982567f.pdf |
| _version_ | 1828486895214002176 |
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| author | Arash Alipour Mohammad Saber Tehrani Parviz Aberoomand Azar Mohammad Hadi Givianrad |
| author_facet | Arash Alipour Mohammad Saber Tehrani Parviz Aberoomand Azar Mohammad Hadi Givianrad |
| author_sort | Arash Alipour |
| collection | DOAJ |
| description | In this research, a novel method is reported for the surface grafting of n-vinylcaprolactam as a thermosensitive agent and 3-allyloxy-1,2-propandiol with an affinity toward ceftriaxone onto modified magnetic nanoparticles by 3-mercaptopropyltrimethoxysilane. The grafted nanoparticles were characterized by Fourier Transform Infrared Spectroscopy, Elemental Analysis, and Vibrating Sample Magnetometer. The surface morphology was studied using Scanning Electron Microscopy. The resulting grafted nanoparticles were used for determining trace ceftriaxone in biological human fluids. The profile of ceftriaxone uptake by the modified magnetic nanoparticles indicated good accessibility of the active sites in the grafted copolymer. It was found that the adsorption behavior could be fitted by the Langmuir adsorption isotherm model. Solid phase extraction for biological fluids such as urine and serum were also investigated. In this study, a urine extraction recovery of more than 95% was obtained. Overall, magnetic nanoparticles coated with sensitive polymer have proved to enjoy unique properties in biotechnology and drug delivery research. |
| first_indexed | 2024-12-11T09:41:11Z |
| format | Article |
| id | doaj.art-a3b74e8997bc441bbd23691a5f2a5811 |
| institution | Directory Open Access Journal |
| issn | 2476-3489 2476-7123 |
| language | English |
| last_indexed | 2024-12-11T09:41:11Z |
| publishDate | 2019-04-01 |
| publisher | Iranian Society of Nanomedicine |
| record_format | Article |
| series | Nanomedicine Research Journal |
| spelling | doaj.art-a3b74e8997bc441bbd23691a5f2a58112022-12-22T01:12:41ZengIranian Society of NanomedicineNanomedicine Research Journal2476-34892476-71232019-04-0142849010.22034/nmrj.2019.02.00535944Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxoneArash Alipour0Mohammad Saber Tehrani1Parviz Aberoomand Azar2Mohammad Hadi Givianrad3Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, IranIn this research, a novel method is reported for the surface grafting of n-vinylcaprolactam as a thermosensitive agent and 3-allyloxy-1,2-propandiol with an affinity toward ceftriaxone onto modified magnetic nanoparticles by 3-mercaptopropyltrimethoxysilane. The grafted nanoparticles were characterized by Fourier Transform Infrared Spectroscopy, Elemental Analysis, and Vibrating Sample Magnetometer. The surface morphology was studied using Scanning Electron Microscopy. The resulting grafted nanoparticles were used for determining trace ceftriaxone in biological human fluids. The profile of ceftriaxone uptake by the modified magnetic nanoparticles indicated good accessibility of the active sites in the grafted copolymer. It was found that the adsorption behavior could be fitted by the Langmuir adsorption isotherm model. Solid phase extraction for biological fluids such as urine and serum were also investigated. In this study, a urine extraction recovery of more than 95% was obtained. Overall, magnetic nanoparticles coated with sensitive polymer have proved to enjoy unique properties in biotechnology and drug delivery research.http://www.nanomedicine-rj.com/article_35944_f9378b44b7a14e57f0350fcf9982567f.pdfmagnetic nanoparticlesdrug deliveryceftriaxone |
| spellingShingle | Arash Alipour Mohammad Saber Tehrani Parviz Aberoomand Azar Mohammad Hadi Givianrad Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone Nanomedicine Research Journal magnetic nanoparticles drug delivery ceftriaxone |
| title | Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone |
| title_full | Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone |
| title_fullStr | Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone |
| title_full_unstemmed | Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone |
| title_short | Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone |
| title_sort | preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone |
| topic | magnetic nanoparticles drug delivery ceftriaxone |
| url | http://www.nanomedicine-rj.com/article_35944_f9378b44b7a14e57f0350fcf9982567f.pdf |
| work_keys_str_mv | AT arashalipour preparationofmodifiedmagneticnanoparticlesforinvitrodeliveryofceftriaxone AT mohammadsabertehrani preparationofmodifiedmagneticnanoparticlesforinvitrodeliveryofceftriaxone AT parvizaberoomandazar preparationofmodifiedmagneticnanoparticlesforinvitrodeliveryofceftriaxone AT mohammadhadigivianrad preparationofmodifiedmagneticnanoparticlesforinvitrodeliveryofceftriaxone |