Targeting Hypoxia-Inducible Factor-1α in Pancreatic Cancer: siRNA Delivery Using Hyaluronic Acid-Displaying Nanoparticles

Targeting Hypoxia-Inducible Factor-1α in Pancreatic Cancer: siRNA Delivery Using Hyaluronic Acid-Displaying Nanoparticles

<b>Background/Objectives:</b> Conventional anticancer therapies often lack specificity, targeting both cancerous and normal cells, which reduces efficacy and leads to undesired off-target effects. An additional challenge is the presence of hypoxic regions in tumors, where the Hypoxia Ind...

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Bibliographic Details
Main Authors: Alice Spadea, Annalisa Tirella, Julio Manuel Rios de la Rosa, Enrique Lallana, Manal Mehibel, Brian Telfer, Nicola Tirelli, Margaret Jayne Lawrence, Kaye J. Williams, Ian J. Stratford, Marianne Ashford
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Pharmaceutics
Subjects:
polymeric nanoparticles
siRNA delivery
cancer
hyaluronic acid
CD44
Online Access:https://www.mdpi.com/1999-4923/16/10/1286

Internet

https://www.mdpi.com/1999-4923/16/10/1286

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