PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites

PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites

Summary: lncRNA taurine-upregulated gene 1 (Tug1) is a promising therapeutic target in the progression of diabetic nephropathy (DN), but the molecular basis of its protection remains poorly understood. Here, we generate a triple-mutant diabetic mouse model coupled with metabolomic profiling data to...

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Bibliographic Details
Main Authors: Li Li, Jianyin Long, Koki Mise, Daniel L. Galvan, Paul A. Overbeek, Lin Tan, Shwetha V. Kumar, Wai Kin Chan, Phillip L. Lorenzi, Benny H. Chang, Farhad R. Danesh
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
RNA
lncRNA
Tug1
PGC1α
podocytes
diabetic nephropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009402

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