Effect of 5α-reductase inhibitors on the efficiency of thulium:yttrium-aluminium-garnet (RevoLix®) vaporesection for treating benign prostatic hyperplasia
Purpose: Preoperative use of 5α-reductase inhibitors (5ARIs) may cause fibrosis of the prostate tissue and reduce the efficiency of thulium laser surgery for treating benign prostate hyperplasia (BPH). Thus, we investigated the effects of preoperative 5ARI use in this setting. Materials and Methods:...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2020-01-01
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| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-67.pdf |
| _version_ | 1818214046267080704 |
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| author | Jae Seung Chung Won Ik Seo Cheol Kyu Oh Seong Cheol Kim Myung Chan Park Sang Hyun Park Jihyeong Yu Chan Ho Lee Wansuk Kim Tae Yong Park Kweon Sik Min Jae Il Chung |
| author_facet | Jae Seung Chung Won Ik Seo Cheol Kyu Oh Seong Cheol Kim Myung Chan Park Sang Hyun Park Jihyeong Yu Chan Ho Lee Wansuk Kim Tae Yong Park Kweon Sik Min Jae Il Chung |
| author_sort | Jae Seung Chung |
| collection | DOAJ |
| description | Purpose: Preoperative use of 5α-reductase inhibitors (5ARIs) may cause fibrosis of the prostate tissue and reduce the efficiency of thulium laser surgery for treating benign prostate hyperplasia (BPH). Thus, we investigated the effects of preoperative 5ARI use in this setting. Materials and Methods: This retrospective study examined 184 patients who underwent thulium laser surgery for BPH during 2012–2017. Patients were grouped according to their 5ARI use in order to compare their preoperative and intraoperative characteristics and subsequent outcomes. Surgical efficiency was assessed using vaporesection efficiency. The total operation time, vaporesection time and prostate volume change were measured. Results: The 5ARI+ group included 83 patients (45.1%) and the 5ARI− group included 101 patients (54.9%). There were no significant differences in the two groups' preoperative characteristics, postoperative prostate size, thulium laser energy use, or prostate volume reduction rate. However, relative to the 5ARI− group, the 5ARI+ group had a significant shorter total operative time (65.0 min vs. 70.0 min, p=0.013) and a significantly shorter vaporesection time (48.0 min vs. 54.0 min, p=0.014), which resulted in significantly higher vaporesection efficiency in the 5ARI+ group (0.66 mL/min vs. 0.51 mL/min, p<0.001). Both groups exhibit significant improvements in their quality of life score and International Prostate Symptom Score during the 12-month follow-up. Conclusions: In contrast with our expectations, the preoperative use of 5ARI increased the efficiency of thulium laser surgery for BPH. Thus, it may not be necessary to stop 5ARI treatment before performing thulium laser surgery in this setting. |
| first_indexed | 2024-12-12T06:13:57Z |
| format | Article |
| id | doaj.art-a3b8f53478614e2484bbd7eaf6630440 |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-12-12T06:13:57Z |
| publishDate | 2020-01-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-a3b8f53478614e2484bbd7eaf66304402022-12-22T00:35:04ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2020-01-01611677410.4111/icu.2020.61.1.67Effect of 5α-reductase inhibitors on the efficiency of thulium:yttrium-aluminium-garnet (RevoLix®) vaporesection for treating benign prostatic hyperplasiaJae Seung Chung0Won Ik Seo1Cheol Kyu Oh2Seong Cheol Kim3Myung Chan Park4Sang Hyun Park5Jihyeong Yu6Chan Ho Lee7Wansuk Kim8Tae Yong Park9Kweon Sik Min10Jae Il Chung11Department of Urology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.Department of Urology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.Department of Urology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.Purpose: Preoperative use of 5α-reductase inhibitors (5ARIs) may cause fibrosis of the prostate tissue and reduce the efficiency of thulium laser surgery for treating benign prostate hyperplasia (BPH). Thus, we investigated the effects of preoperative 5ARI use in this setting. Materials and Methods: This retrospective study examined 184 patients who underwent thulium laser surgery for BPH during 2012–2017. Patients were grouped according to their 5ARI use in order to compare their preoperative and intraoperative characteristics and subsequent outcomes. Surgical efficiency was assessed using vaporesection efficiency. The total operation time, vaporesection time and prostate volume change were measured. Results: The 5ARI+ group included 83 patients (45.1%) and the 5ARI− group included 101 patients (54.9%). There were no significant differences in the two groups' preoperative characteristics, postoperative prostate size, thulium laser energy use, or prostate volume reduction rate. However, relative to the 5ARI− group, the 5ARI+ group had a significant shorter total operative time (65.0 min vs. 70.0 min, p=0.013) and a significantly shorter vaporesection time (48.0 min vs. 54.0 min, p=0.014), which resulted in significantly higher vaporesection efficiency in the 5ARI+ group (0.66 mL/min vs. 0.51 mL/min, p<0.001). Both groups exhibit significant improvements in their quality of life score and International Prostate Symptom Score during the 12-month follow-up. Conclusions: In contrast with our expectations, the preoperative use of 5ARI increased the efficiency of thulium laser surgery for BPH. Thus, it may not be necessary to stop 5ARI treatment before performing thulium laser surgery in this setting.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-67.pdflaser therapyprostatic hyperplasiathulium5-alpha reductase inhibitors |
| spellingShingle | Jae Seung Chung Won Ik Seo Cheol Kyu Oh Seong Cheol Kim Myung Chan Park Sang Hyun Park Jihyeong Yu Chan Ho Lee Wansuk Kim Tae Yong Park Kweon Sik Min Jae Il Chung Effect of 5α-reductase inhibitors on the efficiency of thulium:yttrium-aluminium-garnet (RevoLix®) vaporesection for treating benign prostatic hyperplasia Investigative and Clinical Urology laser therapy prostatic hyperplasia thulium 5-alpha reductase inhibitors |
| title | Effect of 5α-reductase inhibitors on the efficiency of thulium:yttrium-aluminium-garnet (RevoLix®) vaporesection for treating benign prostatic hyperplasia |
| title_full | Effect of 5α-reductase inhibitors on the efficiency of thulium:yttrium-aluminium-garnet (RevoLix®) vaporesection for treating benign prostatic hyperplasia |
| title_fullStr | Effect of 5α-reductase inhibitors on the efficiency of thulium:yttrium-aluminium-garnet (RevoLix®) vaporesection for treating benign prostatic hyperplasia |
| title_full_unstemmed | Effect of 5α-reductase inhibitors on the efficiency of thulium:yttrium-aluminium-garnet (RevoLix®) vaporesection for treating benign prostatic hyperplasia |
| title_short | Effect of 5α-reductase inhibitors on the efficiency of thulium:yttrium-aluminium-garnet (RevoLix®) vaporesection for treating benign prostatic hyperplasia |
| title_sort | effect of 5α reductase inhibitors on the efficiency of thulium yttrium aluminium garnet revolix r vaporesection for treating benign prostatic hyperplasia |
| topic | laser therapy prostatic hyperplasia thulium 5-alpha reductase inhibitors |
| url | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-67.pdf |
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