Evx2-Hoxd13 intergenic region restricts enhancer association to Hoxd13 promoter.

Evx2-Hoxd13 intergenic region restricts enhancer association to Hoxd13 promoter.

Expression of Hox genes is tightly regulated in spatial and temporal domains. Evx2 is located next to Hoxd13 within 8 kb on the opposite DNA strand. Early in development, the pattern of Hoxd13 expression resembles that of Evx2 in limb and genital buds. After 10 dpc, however, Evx2 begins to be expres...

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Bibliographic Details
Main Authors: Takumi Yamagishi, Michiru Ozawa, Chiho Ohtsuka, Ritsuko Ohyama-Goto, Takashi Kondo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1766471?pdf=render

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